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Species-Specific Secondary Metabolite Production in Marine Actinomycetes of the Genus Salinispora

机译：盐藻属海洋放线菌中特定物种的次生代谢产物的产生

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Here we report associations between secondary metabolite production and phylogenetically distinct but closely related marine actinomycete species belonging to the genus Salinispora. The pattern emerged in a study that included global collection sites, and it indicates that secondary metabolite production can be a species-specific, phenotypic trait associated with broadly distributed bacterial populations. Associations between actinomycete phylotype and chemotype revealed an effective, diversity-based approach to natural product discovery that contradicts the conventional wisdom that secondary metabolite production is strain specific. The structural diversity of the metabolites observed, coupled with gene probing and phylogenetic analyses, implicates lateral gene transfer as a source of the biosynthetic genes responsible for compound production. These results conform to a model of selection-driven pathway fixation occurring subsequent to gene acquisition and provide a rare example in which demonstrable physiological traits have been correlated to the fine-scale phylogenetic architecture of an environmental bacterial community.
机译：在这里，我们报告二级代谢产物的生产与系统发育上独特但密切相关的属于盐藻属的海洋放线菌物种之间的关联。该模式出现在一项包括全球收集地点的研究中，它表明次生代谢产物的产生可能是与广泛分布的细菌种群相关的物种特异性表型性状。放线菌的系统型和化学型之间的关联揭示了一种有效的，基于多样性的天然产物发现方法，该方法与次生代谢产物产生是菌株特异性的传统观点相矛盾。观察到的代谢物的结构多样性，再加上基因探测和系统发育分析，表明侧向基因转移是负责化合物生产的生物合成基因的来源。这些结果符合在基因获取后发生的选择驱动途径固定的模型，并提供了一个罕见的例子，其中可证实的生理特征已与环境细菌群落的精细系统发育结构相关。

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