Overexpression of the 14α-Demethylase Target Gene (CYP51) Mediates Fungicide Resistance in Blumeriella jaapii

Zhonghua Ma; Tyre J. Proffer; Janette L. Jacobs; George W. Sundin

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Overexpression of the 14α-Demethylase Target Gene (CYP51) Mediates Fungicide Resistance in Blumeriella jaapii

机译：14α-脱甲基酶靶基因（CYP51）的过表达介导了日本小球藻的杀菌剂抗性。

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Sterol demethylation inhibitor (DMI) fungicides are widely used to control fungi pathogenic to humans and plants. Resistance to DMIs is mediated either through alterations in the structure of the target enzyme CYP51 (encoding 14α-demethylase), through increased expression of the CYP51 gene, or through increased expression of efflux pumps. We found that CYP51 expression in DMI-resistant (DMIR) isolates of the cherry leaf spot pathogen Blumeriella jaapii was increased 5- to 12-fold compared to that in DMI-sensitive (DMIS) isolates. Analysis of sequences upstream of CYP51 in 59 DMIR isolates revealed that various forms of a truncated non-long terminal direct repeat long interspersed nuclear element retrotransposon were present in all instances. Similar inserts upstream of CYP51 were not present in any of 22 DMIS isolates examined.

机译：甾醇去甲基化抑制剂（DMI）杀菌剂被广泛用于控制对人类和植物致病的真菌。对DMI的抗性通过靶酶CYP51（编码14α-脱甲基酶）结构的改变，CYP51基因表达的增加或外排泵表达的增加来介导。我们发现，与DMI敏感（DMIS）隔离株相比，樱桃叶斑病病原体布鲁默氏菌（Blumerella jaapii）的DMI抗性（DMIR）隔离株中的CYP51表达增加了5至12倍。对59份DMIR分离物中CYP51上游序列的分析显示，在所有情况下均存在各种形式的截短的非长末端直接重复长散布的核元件反转录转座子。在所检查的22个DMIS分离物中，没有CYP51上游的相似插入片段。

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《Applied and Environmental Microbiology》 |2006年第4期|共5页
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Zhonghua Ma; Tyre J. Proffer; Janette L. Jacobs; George W. Sundin;
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1. Overexpression of the 14α-Demethylase Target Gene (CYP51) Mediates Fungicide Resistance in Blumeriella jaapii [J] . Zhonghua Ma, Tyre J. Proffer, Janette L. Jacobs, Applied and Environmental Microbiology . 2006,第4期

机译：14α-脱甲基酶靶基因（CYP51）的过表达介导了日本小球藻的杀菌剂抗性。
2. Demethylase Inhibitor Fungicide Resistance in Pyrenophora teres f. sp. teres Associated with Target Site Modification and Inducible Overexpression of Cyp51 [J] . Wesley J. Mair, Weiwei Deng, Jonathan G. L. Mullins, Frontiers in Microbiology . 2016,第6期

机译：f。斜纹夜蛾对脱甲基酶抑制剂的杀菌剂抗性。 sp。 teres 与靶位点修饰和 Cyp51 的诱导过表达相关
3. Induced overexpression of cytochrome P450 sterol 14α-demethylase gene (CYP51) correlates with sensitivity to demethylation inhibitors (DMis) in Sclerotinia homoeocarpa [J] . Bangya Ma, Lane P Tredway Pest Management Science . 2013,第12期

机译：诱导的细胞色素P450甾醇14α-脱甲基酶基因（CYP51）的过表达与高果核盘菌对去甲基化抑制剂（DMis）的敏感性相关
4. Tandem repeat of a transcriptional enhancer upstream of the sterol 14 A-demethylase gene (CYP51) for fungicide-resistance in Penicillium digitatum [C] . Hiroshi Hamamoto, Koji Hasegawa, Ryoji Nakaune, Asian conference on plant pathology . 2000

机译：甾醇14 A-Demethylase基因（CYP51）上游的转录增强剂的转录增强剂的串联重复，用于青霉磷酸酯抗性
5. Host-Induced Gene Silencing (HIGS) of the Fungal Cytochrome P450 Lanosterol C-14A-Demethylase (CYP51) Could Confer Resistance to Fusarium verticillioides in Maize [D] . Crenshaw, Nicole Jozwiak. 2020

机译：真菌细胞色素P450 Lanterol醇C-14A-脱甲基酶（CYP51）的宿主诱导的基因沉默（HIGS）可以赋予玉米中镰刀菌的镰刀菌
6. Overexpression of the 14α-Demethylase Target Gene (CYP51) Mediates Fungicide Resistance in Blumeriella jaapii [O] . Zhonghua Ma, Tyre J. Proffer, Janette L. Jacobs, 2006

机译：14α-脱甲基酶靶基因（CYP51）的过表达介导了日本小球藻的杀菌剂抗性。
7. Overexpression of the 14α-Demethylase Target Gene (CYP51) Mediates Fungicide Resistance in Blumeriella jaapii [O] . Ma, Zhonghua, Proffer, Tyre J., Jacobs, Janette L., 2006

机译：14α-脱甲基酶靶基因（CYP51）的过表达介导了日本小球藻的杀菌剂抗性。
8. Primary Structure of the Cytochrome P450 Lanosterol 14 alpha-Demethylase Gene from 'Candida tropicalis' [R] . Chen, C., Kalb, V. F., Turi, T. G., 1988

机译：来自'Candida tropicalis'的细胞色素p450羊毛甾醇14α-去甲基化酶基因的一级结构

Overexpression of the 14α-Demethylase Target Gene (CYP51) Mediates Fungicide Resistance in Blumeriella jaapii

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