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首页> 外文期刊>Applied and Environmental Microbiology >Genome-Scale Model of Streptococcus thermophilus LMG18311 for Metabolic Comparison of Lactic Acid Bacteria
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Genome-Scale Model of Streptococcus thermophilus LMG18311 for Metabolic Comparison of Lactic Acid Bacteria

机译：嗜热链球菌LMG18311的基因组规模模型用于乳酸菌代谢比较

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In this report, we describe the amino acid metabolism and amino acid dependency of the dairy bacterium Streptococcus thermophilus LMG18311 and compare them with those of two other characterized lactic acid bacteria, Lactococcus lactis and Lactobacillus plantarum. Through the construction of a genome-scale metabolic model of S. thermophilus, the metabolic differences between the three bacteria were visualized by direct projection on a metabolic map. The comparative analysis revealed the minimal amino acid auxotrophy (only histidine and methionine or cysteine) of S. thermophilus LMG18311 and the broad variety of volatiles produced from amino acids compared to the other two bacteria. It also revealed the limited number of pyruvate branches, forcing this strain to use the homofermentative metabolism for growth optimization. In addition, some industrially relevant features could be identified in S. thermophilus, such as the unique pathway for acetaldehyde (yogurt flavor) production and the absence of a complete pentose phosphate pathway.
机译：在本报告中，我们描述了乳杆菌嗜热链球菌LMG18311的氨基酸代谢和氨基酸依赖性，并将它们与其他两种表征的乳酸菌（乳酸乳球菌和植物乳杆菌）进行了比较。通过构建嗜热链球菌的基因组规模的代谢模型，可通过直接投影在代谢图上来可视化三种细菌之间的代谢差异。对比分析显示，与其他两种细菌相比，嗜热链球菌LMG18311的氨基酸营养缺陷最少（仅组氨酸和蛋氨酸或半胱氨酸），氨基酸产生的挥发物种类繁多。它还揭示了丙酮酸分支的数量有限，迫使该菌株利用同型发酵代谢来优化生长。另外，在嗜热链球菌中可以鉴定出一些与工业相关的特征，例如乙醛（酸奶味）生产的独特途径和不存在完整的戊糖磷酸途径。

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