Rat Pyelonephritis Model Suitable for Primary or Secondary Screening

S. E. Burrous; J. B. Cawein

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Rat Pyelonephritis Model Suitable for Primary or Secondary Screening

机译：适用于初次或二次筛查的大鼠肾盂肾炎模型

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A rat Proteus and Escherichia pyelonephritis model is described in which (i) reproducible chronic infections are achieved and (ii) the efficacy of clinically effective agents is reliably demonstrable with five rats in 17 days. It can serve as a primary screen in which one technician can evaluate 180 compounds per month with 900 rats. The manner of inoculation will inherently allow the study of and distinction between metabolism which is peculiar to infection and that which is characteristic of trauma and healing in general for the elucidation of chemical correlations with effective therapy.

机译：描述了大鼠变形杆菌和大肠杆菌肾盂肾炎模型，其中（i）实现了可重现的慢性感染，并且（ii）在17天内有五只大鼠可靠地证明了临床有效药物的功效。它可以用作主要筛选，一个技术人员每月可以评估900只大鼠的180种化合物。接种方式将固有地允许研究和区分感染特有的代谢和通常为创伤和愈合所特有的代谢，以阐明与有效疗法的化学相关性。

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《Applied Microbiology》 |1969年第3期|共4页
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S. E. Burrous; J. B. Cawein;
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中图分类微生物学;
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6. Rat Pyelonephritis Model Suitable for Primary or Secondary Screening [O] . S. E. Burrous, J. B. Cawein 1969

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Rat Pyelonephritis Model Suitable for Primary or Secondary Screening

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