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首页> 外文期刊>Applied and Environmental Microbiology >Mortality Caused by Bath Exposure of Zebrafish (Danio rerio) Larvae to Nervous Necrosis Virus Is Limited to the Fourth Day Postfertilization
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Mortality Caused by Bath Exposure of Zebrafish (Danio rerio) Larvae to Nervous Necrosis Virus Is Limited to the Fourth Day Postfertilization

机译：斑马鱼（达尼奥里奥）幼虫洗澡暴露于神经坏死病毒引起的死亡率仅限于受精后的第四天

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Nervous necrosis virus (NNV) is a member of the Betanodavirus genus that causes fatal diseases in over 40 species of fish worldwide. Mortality among NNV-infected fish larvae is almost 100%. In order to elucidate the mechanisms responsible for the susceptibility of fish larvae to NNV, we exposed zebrafish larvae to NNV by bath immersion at 2, 4, 6, and 8 days postfertilization (dpf). Here, we demonstrate that developing zebrafish embryos are resistant to NNV at 2 dpf due to the protection afforded by the egg chorion and, to a lesser extent, by the perivitelline fluid. The zebrafish larvae succumbed to NNV infection during a narrow time window around the 4th dpf, while 6- and 8-day-old larvae were much less sensitive, with mortalities of 24% and 28%, respectively.
机译：神经坏死病毒（NNV）是Betanodavirus属的成员，在全世界40多种鱼类中引起致命疾病。 NNV感染的鱼幼虫的死亡率几乎为100％。为了阐明造成鱼幼虫对NNV易感性的机制，我们在受精后2、4、6和8天通过浸浴将斑马鱼幼虫暴露于NNV。在这里，我们证明发育中的斑马鱼胚胎在2 dpf时对NNV有抗性，这是由于卵绒毛膜和（在较小程度上）卵白质液提供的保护。斑马鱼幼虫在第4 dpf左右的狭窄时间窗内死于NNV感染，而6日龄和8日龄的幼虫敏感度低得多，死亡率分别为24％和28％。

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