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Amphotericin B Serum Concentrations During Therapy

机译：治疗期间两性霉素B的血清浓度

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Therapeutic outcome of patients being treated for systemic mycoses with amphotericin B is possibly related to the serum concentrations of this drug that are produced in these patients. Because current data are conflicting, the magnitude of these concentrations was restudied by using a bioassay which gave precise and accurate results. The highest of 155 serum concentrations was 2.01 μg/ml. Mean concentrations were 1.21, 0.62, and 0.32 μg/ml, at 1, 18, and 42 hr, respectively, after intravenous infusion of amphotericin B. This drug was detected in serum 7 weeks after completion of treatment, but it could not be detected 13 weeks after treatment. Drug levels did not appreciably decrease in serum stored for 8 to 9 months at ? 10 C. Unequal serum content in assay tubes and measurement of assay turbidity by visual inspection may explain previously reported amphotericin B levels of 3.0 to 12.5 μg/ml.
机译：用两性霉素B治疗全身性真菌病的患者的治疗结果可能与这些患者产生的该药物的血清浓度有关。由于当前数据相互矛盾，因此使用生物测定法对这些浓度的大小进行了重新评估，该测定法给出了准确而准确的结果。 155个血清浓度的最高值为2.01μg/ ml。静脉内注射两性霉素B后，分别在第1、18和42小时的平均浓度分别为1.21、0.62和0.32μg/ ml。在完成治疗后7周，该药物在血清中检测到，但未检测到治疗后13周。在室温下储存8至9个月的血清中的药物水平没有明显下降。 10 C.试管中的血清含量不相等以及通过目视检查测定浊度可能解释了先前报道的两性霉素B水平为3.0至12.5μg/ ml。

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