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首页> 外文期刊>Applied Microbiology >Interaction of Mycobacterium ulcerans with Mosquito Species: Implications for Transmission and Trophic Relationships
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Interaction of Mycobacterium ulcerans with Mosquito Species: Implications for Transmission and Trophic Relationships

机译：溃疡分枝杆菌与蚊子物种的相互作用：对传播和营养关系的影响。

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Mycobacterium ulcerans is the causative agent of Buruli ulcer, a severe necrotizing skin disease that causes significant morbidity in Africa and Australia. Person-to-person transmission of Buruli ulcer is rare. Throughout Africa and Australia infection is associated with residence near slow-moving or stagnant water bodies. Although M. ulcerans DNA has been detected in over 30 taxa of invertebrates, fish, water filtrate, and plant materials and one environmental isolate cultured from a water strider (Gerridae), the invertebrate taxa identified are not adapted to feed on humans, and the mode of transmission for Buruli ulcer remains an enigma. Recent epidemiological reports from Australia describing the presence of M. ulcerans DNA in adult mosquitoes have led to the hypothesis that mosquitoes play an important role in the transmission of M. ulcerans. In this study we have investigated the potential of mosquitoes to serve as biological or mechanical vectors or as environmental reservoirs for M. ulcerans . Here we show that Aedes aegypti , A. albopictus , Ochlerotatus triseriatus , and Culex restuans larvae readily ingest wild-type M. ulcerans , isogenic toxin-negative mutants, and Mycobacterium marinum isolates and remain infected throughout larval development. However, the infections are not carried over into the pupae or adult mosquitoes, suggesting an unlikely role for mosquitoes as biological vectors. By following M. ulcerans through a food chain consisting of primary (mosquito larvae), secondary (predatory mosquito larva from Toxorhynchites rutilus septentrionalis ), and tertiary ( Belostoma species) consumers, we have shown that M. ulcerans can be productively maintained in an aquatic food web.
机译：溃疡分枝杆菌是布鲁氏溃疡的病原体，布鲁氏溃疡是一种严重的坏死性皮肤病，在非洲和澳大利亚引起严重的发病。布鲁里溃疡的人际传播很少。在整个非洲和澳大利亚，感染与靠近缓慢移动或停滞的水体的住所有关。尽管已在30多种无脊椎动物，鱼类，水滤液和植物材料以及从水ider（Gerridae）培养的一种环境分离物中检测到溃疡分枝杆菌DNA，但鉴定出的无脊椎动物分类不适合以人类为食。布鲁里溃疡的传播方式仍然是一个谜。澳大利亚最近的流行病学报告描述了成年蚊中存在溃疡分枝杆菌DNA，这导致了以下假设：蚊子在溃疡分枝杆菌的传播中起着重要作用。在这项研究中，我们研究了蚊子作为溃疡分支杆菌的生物或机械载体或环境贮藏物的潜力。在这里，我们显示埃及伊蚊，白纹伊蚊，白粉虱，和库克斯rest幼虫很容易摄入野生型溃疡分支杆菌，等基因毒素阴性突变体和海洋分枝杆菌分离株，并且在整个幼虫发育过程中仍然受到感染。但是，感染并未传播到the或成年蚊子中，这表明蚊子作为生物载体的作用不太可能。通过在由原发性（蚊子幼虫），继发性（来自Toxorhynchites rut​​ilus septentrionalis的捕食性蚊子幼虫）和第三类（贝洛斯托马种）消费者组成的食物链中追踪溃疡分枝杆菌，我们证明了溃疡分枝杆菌可以在水生动物中高效生产食物网。

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