Two Novel Toxin Variants Revealed by Whole-Genome Sequencing of 175 Clostridium botulinum Type E Strains

K. A. Weedmark; D. L. Lambert; P. Mabon; K. L. Hayden; C. J. Urfano; D. Leclair; G. Van Domselaar; J. W. Austin; C. R. Corbett

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Two Novel Toxin Variants Revealed by Whole-Genome Sequencing of 175 Clostridium botulinum Type E Strains

机译：175个E型肉毒梭菌全基因组测序揭示了两个新型毒素变异体

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We sequenced 175 Clostridium botulinum type E strains isolated from food, clinical, and environmental sources from northern Canada and analyzed their botulinum neurotoxin (bont) coding sequences (CDSs). In addition to bont/E1 and bont/E3 variant types, neurotoxin sequence analysis identified two novel BoNT type E variants termed E10 and E11. Strains producing type E10 were found along the eastern coastlines of Hudson Bay and the shores of Ungava Bay, while strains producing type E11 were only found in the Koksoak River region of Nunavik. Strains producing BoNT/E3 were widespread throughout northern Canada, with the exception of the coast of eastern Hudson Bay.

机译：我们对从加拿大北部的食物，临床和环境来源分离出的175株梭状芽孢梭菌进行了测序，并分析了它们的肉毒杆菌神经毒素（bont）编码序列（CDS）。除了bont / E1和bont / E3变体类型之外，神经毒素序列分析还确定了两个新的BoNT E型变体，称为E10和E11。在哈德逊湾的东部海岸线和翁加瓦湾沿岸发现了产生E10型的菌株，而仅在努纳维克的科索克河地区发现了产生E11型的菌株。产生BoNT / E3的菌株遍及加拿大北部，哈德逊湾东部沿海除外。

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《Applied and Environmental Microbiology》 |2014年第20期|共12页
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K. A. Weedmark; D. L. Lambert; P. Mabon; K. L. Hayden; C. J. Urfano; D. Leclair; G. Van Domselaar; J. W. Austin; C. R. Corbett;
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1. Two Novel Toxin Variants Revealed by Whole-Genome Sequencing of 175 Clostridium botulinum Type E Strains [J] . K. A. Weedmark, D. L. Lambert, P. Mabon, Applied Microbiology . 2014,第20期

机译：175个E型肉毒梭菌全基因组测序揭示了两个新型毒素变异体
2. Sequencing the Botulinum Neurotoxin Gene and Related Genes in Clostridium botulinum Type E Strains Reveals orfx3 and a Novel Type E Neurotoxin Subtype [J] . Ying Chen, Hannu Korkeala, Johannes Aarnikunnas, Journal of bacteriology . 2007,第23期

机译：肉毒梭菌E型菌株肉毒杆菌神经毒素基因及相关基因的测序揭示了orfx3和新型E型神经毒素亚型
3. Taxonomic identity of type E botulinum toxin-producing Clostridium butyricum strains by sequencing of a short 16S rDNA region [J] . Pourshaban M., Franciosa G., Fenicia L., FEMS Microbiology Letters . 2002,第1期

机译：通过短的16S rDNA区域测序确定E型肉毒杆菌产丁酸梭菌菌株的生物分类
4. THE STUDY OF TOXIN TYPES OF CLOSTRIDIUM BOTULINUM IN FRESH AND SMOKED CULTIVATED FISHES OF IRAN [C] . H.R.Tavakoli, V.Razavilar International Conference of the European Aquaculture Society . 2004

机译：伊朗新鲜和熏制培育鱼中毒素类型的毒素类型研究
5. Analysis of type A botulinum neurotoxin expression in Clostridium botulinum. [D] . Dineen, Sean S. 2003

机译：分析肉毒梭菌中A型肉毒杆菌神经毒素的表达。
6. Two Novel Toxin Variants Revealed by Whole-Genome Sequencing of 175 Clostridium botulinum Type E Strains [O] . K. A. Weedmark, D. L. Lambert, P. Mabon, 2014

机译：175个E型肉毒梭菌全基因组测序揭示了两个新型毒素变异体
7. Two Novel Toxin Variants Revealed by Whole-Genome Sequencing of 175 Clostridium botulinum Type E Strains [O] . K. A. Weedmark, D. L. Lambert, P. Mabon, 2014

机译：通过175个梭菌肉毒杆菌型E株的全基因组测序揭示了两种新型毒素变体
8. Recombination and Insertion Events Involving the Botulinum Neurotoxin Complex Genes in Clostridium botulinum Types A, B, E and F and Clostridium butyricum Type E Strains [R] . Hill, K. K., Xie, G., Foley, B. T., 2009

机译：a型，B型，E型和a型梭菌属肉毒杆菌和E型梭菌属肉毒杆菌神经毒素复合基因的重组和插入事件

Two Novel Toxin Variants Revealed by Whole-Genome Sequencing of 175 Clostridium botulinum Type E Strains

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