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首页> 外文期刊>Applied Microbiology >Effects of Amphotericin B In Vitro on Perfect and Imperfect Strains of Allescheria boydii
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Effects of Amphotericin B In Vitro on Perfect and Imperfect Strains of Allescheria boydii

机译：两性霉素B体外对波氏Allescheria完美和不完美菌株的影响

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The inhibitory effects of amphotericin B on Allescheria boydii vary with the strain studied. In general, most isolates of the fungus are not susceptible to concentrations within the range of human tolerance. This is particularly true of perfect forms, although this relationship is lacking for some isolates. There is no correlation between the isolation history of a strain and its amphotericin B sensitivity. Susceptibility was found to be absolute in some isolates, whereas resistance could be increased in others through repeated exposure to higher increments of drug. In high concentrations, the antibiotic is uniformly cidal for the spores of certain isolates. This finding was also true for some conidia of “resistant” strains, although the action was fungistatic on other spores in the same population.
机译：两性霉素B对波氏Allescheria的抑制作用随所研究菌株的不同而不同。通常，大多数真菌分离物对人类耐受范围内的浓度不敏感。完美形式尤其如此，尽管某些分离物缺乏这种关系。菌株的分离史与其两性霉素B敏感性之间没有相关性。在某些菌株中，药敏性是绝对的，而在另一些菌株中，耐药性可以通过反复接触更高剂量的药物而增加。在高浓度下，抗生素对某些分离物的孢子具有均匀的杀灭作用。这一发现对于某些“抗药性”分生孢子分生孢子也是正确的，尽管该作用对同一种群中的其他孢子具有抑真菌作用。

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