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Microbiological Study of Copiamycin

机译:卡波霉素的微生物学研究

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Copiamycin, an antibiotic agent, has shown in vitro activity against Candida albicans, Torulopsis glabrata, and Trichomonas vaginalis. Local administration of copiamycin to mice inoculated intraperitoneally with protozoa reduced the per cent of infection as measured by decreased abscess formation. This antibiotic has had little effect on the glucose oxidation by protozoa. Its action on anaerobic glucose metabolism in these organisms was equal to that of aminitrozole and azalomycin F. From these results we conclude that copiamycin is an effective antifungal and antitrichomonal agent equivalent in activity to azalomycin F.
机译:抗菌素Copiamycin已显示出对白色念珠菌,光滑拟弧菌和阴道毛滴虫的体外活性。对腹腔内接种原生动物的小鼠局部给予卡拜霉素可减少脓肿的形成,从而降低感染率。这种抗生素对原生动物的葡萄糖氧化作用很小。它在这些生物体中对厌氧葡萄糖代谢的作用与阿米诺唑和阿扎霉素F的作用相同。从这些结果,我们得出结论,卡培霉素是一种等效于阿扎霉素F的有效抗真菌和抗滴虫药。

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