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首页> 外文期刊>Applied Microbiology >Characterization of the Precipitin Bands Detected in the Immunodiffusion Test for Paracoccidioidomycosis
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Characterization of the Precipitin Bands Detected in the Immunodiffusion Test for Paracoccidioidomycosis

机译：在旁扩散球菌免疫扩散测试中检测到的沉淀蛋白带的表征。

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摘要

In order to characterize the precipitin bands detected in the immunodiffusion test for paracoccidioidomycosis, a study was undertaken in 54 patients with the disease. On the basis of the pattern of known control sera, the three commonly observed lines of precipitate were designated as 1, 2, and 3 according to their location in the immunodiffusion plate. At time of diagnosis, 28 of the patients exhibited all three bands, 16 gave two bands, and 10 showed only one precipitin line. Over 50 of the sera with three bands had high complement fixation titers (above 1:512), whereas those with one band exhibited lower titers. A similar picture was obtained with the quantitative agar-gel techniques, where titers of 1:64 and above were more commonly observed in sera with three precipitin lines. Follow-up studies carried out in 18 patients revealed that band 3 disappeared first, followed by band 2, and, finally, by band 1. At the end of 2 to 3 years, 85.7% of the patients had lost band 3, 75% band 2, and only 27.7% band 1. Cross-reactions with histoplasmin were found in eight patients who gave the M precipitin line with this antigen. It was found that the latter band and our paracoccidioidin band 3 fused, producing lines of identity. Bands 1 and 2 were specific. The implications of these findings are discussed.
机译：为了表征在球虫副球菌病的免疫扩散试验中检测到的沉淀蛋白条带，对54例该病患者进行了研究。根据已知对照血清的模式，根据其在免疫扩散板上的位置，将三种常见的沉淀物线指定为1、2和3。在诊断时，28例患者显示所有三个谱带，16例显示两个谱带，10例仅显示一条沉淀蛋白。具有三个谱带的血清中超过50个具有较高的补体固定效价（1：512以上），而具有一个谱带的血清则具有较低的效价。用定量琼脂凝胶技术获得了相似的图像，其中在三个沉淀蛋白系的血清中更常见的是1:64和更高的滴度。对18位患者进行的随访研究显示，第3频段先消失，然后消失为2频段，最后消失为第1频段。在2至3年结束时，有85.7％的患者失去了3频段，75％在第2条带中，只有27.7％的第1条带。在有M沉淀蛋白系与该抗原结合的八名患者中发现了与组织浆蛋白的交叉反应。发现后者的条带和我们的副球蛋白带3融合在一起，产生同一性。频段1和2是特定的。讨论了这些发现的含义。

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