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首页> 外文期刊>Applied Microbiology >Effect of Naturally Occurring Xanthines on Bacteria I. Antimicrobial Action and Potentiating Effect on Antibiotic Spectra
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Effect of Naturally Occurring Xanthines on Bacteria I. Antimicrobial Action and Potentiating Effect on Antibiotic Spectra

机译：天然存在的黄嘌呤对细菌的影响I.抗菌作用和对抗菌谱的增强作用

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The effect of xanthines on various microorganisms was studied. The antibacterial effect was not high; most of the test organisms could easily withstand a concentration of 2,500 μg/ml. Caffeine was more antibacterial than theophylline, and the latter more than theobromine. Caffeine citrate exhibited greater inhibitory effect than did pure caffeine. The effect was both bacteriostatic and bactericidal against susceptible organisms. The susceptibility of organisms to xanthines differed greatly even in related species. The morphology of Aerobacter aerogenes and A. cloacae was affected under the influence of caffeine; filamentation of cells followed sublethal doses. Potentiation was seen with antibiotics and caffeine; resistant strains were killed with a lower dose of drug in the presence of caffeine. This potentiating effect was pronounced with the tetracyclines; with streptomycin, the effect was the contrary.
机译：研究了黄嘌呤对各种微生物的作用。抗菌效果不高;大多数测试生物都可以轻松承受2500μg/ ml的浓度。咖啡因比茶碱具有更好的抗菌作用，而咖啡因比可可碱更强。柠檬酸咖啡因比纯咖啡因表现出更大的抑制作用。其作用是对易感生物具有抑菌和杀菌作用。即使在相关物种中，生物体对黄嘌呤的敏感性也大不相同。在咖啡因的影响下，Aerobacter aerogenes和A. cloacae的形态受到影响。亚致死剂量后细胞丝化。抗生素和咖啡因增强了作用。在咖啡因存在下，用较低剂量的药物杀死抗药性菌株。四环素具有明显的增强作用。对于链霉素，效果相反。

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