Tumor Necrosis Factor Alpha Modulates the Dynamics of the Plasminogen-Mediated Early Interaction between Bifidobacterium animalis subsp. lactis and Human Enterocytes

Manuela Centanni; Simone Bergmann; Silvia Turroni; Sven Hammerschmidt; Gursharan Singh Chhatwal; Patrizia Brigidi; Marco Candela

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Tumor Necrosis Factor Alpha Modulates the Dynamics of the Plasminogen-Mediated Early Interaction between Bifidobacterium animalis subsp. lactis and Human Enterocytes

机译：肿瘤坏死因子α调节动物双歧杆菌亚种之间的纤溶酶介导的早期相互作用的动力学。乳酸和人类肠上皮细胞

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The capacity to intervene with the host plasminogen system has recently been considered an important component in the interaction process between Bifidobacterium animalis subsp. lactis and the human host. However, its significance in the bifidobacterial microecology within the human gastrointestinal tract is still an open question. Here we demonstrate that human plasminogen favors the B. animalis subsp. lactis BI07 adhesion to HT29 cells. Prompting the HT29 cell capacity to activate plasminogen, tumor necrosis factor alpha (TNF-α) modulated the plasminogen-mediated bacterium-enterocyte interaction, reducing the bacterial adhesion to the enterocytes and enhancing migration to the luminal compartment.

机译：近来，干扰宿主纤溶酶原系统的能力被认为是动物双歧杆菌亚种之间相互作用过程的重要组成部分。乳酸和人类宿主。然而，其在人胃肠道内双歧杆菌微生态学中的意义仍然是一个悬而未决的问题。在这里，我们证明了人类纤溶酶原有利于B. animalis亚种。乳酸BI07对HT29细胞的粘附。肿瘤坏死因子α（TNF-α）促进了HT29细胞激活纤溶酶原的能力，调节了纤溶酶原介导的细菌-肠细胞相互作用，减少了细菌对肠上皮细胞的粘附并增强了向腔腔的迁移。

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《Applied and Environmental Microbiology》 |2012年第7期|共5页
作者
Manuela Centanni; Simone Bergmann; Silvia Turroni; Sven Hammerschmidt; Gursharan Singh Chhatwal; Patrizia Brigidi; Marco Candela;
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1. Tumor Necrosis Factor Alpha Modulates the Dynamics of the Plasminogen-Mediated Early Interaction between Bifidobacterium animalis subsp. lactis and Human Enterocytes [J] . Manuela Centanni, Simone Bergmann, Silvia Turroni, Applied and Environmental Microbiology . 2012,第7期

机译：肿瘤坏死因子α调节动物双歧杆菌亚种之间的纤溶酶介导的早期相互作用的动力学。乳酸和人类肠上皮细胞
2. Tumor Necrosis Factor Alpha Modulates the Dynamics of the Plasminogen-Mediated Early Interaction between Bifidobacterium animalis subsp. lactis and Human Enterocytes [J] . Manuela Centanni, Simone Bergmann, Silvia Turroni, Applied Microbiology . 2012,第7期

机译：肿瘤坏死因子α调节动物双歧杆菌亚种之间的纤溶酶介导的早期相互作用的动力学。乳酸和人类肠上皮细胞
3. Bifidobacterium animalis ssp. lactis BI07 modulates the tumor necrosis factor alpha-dependent imbalances of the enterocyteassociated intestinal microbiota fraction [J] . Manuela Centanni, Silvia Turroni, Simone Rampelli, FEMS Microbiology Letters . 2014,第2期

机译：动物双歧杆菌乳酸BI07调节肠细胞相关的肠道菌群分数的肿瘤坏死因子α依赖性失衡
4. A HDX/MS analysis of the interaction between human tumor necrosis factor-alpha (TNFα) and anti-TNFαagents [C] . Shiori Nakazawa, Noritaka Hashii, Nana Kawasaki American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：HDX / MS分析人肿瘤坏死因子-α（TNFα）和抗TNFα之间的相互作用
5. A study on the effect of delivery vehicles on the efficacy of Bifidobacterium animalis subsp. lactis BB-12 in humans. [D] . Ba, Zhaoyong. 2016

机译：运载工具对动物双歧杆菌亚种功效的影响研究。人类乳杆菌BB-12。
6. Tumor Necrosis Factor Alpha Modulates the Dynamics of the Plasminogen-Mediated Early Interaction between Bifidobacterium animalis subsp. lactis and Human Enterocytes [O] . Manuela Centanni, Simone Bergmann, Silvia Turroni, 2012

机译：肿瘤坏死因子α调节动物双歧杆菌亚种之间的纤溶酶原介导的早期相互作用的动力学。乳酸和人类肠上皮细胞
7. Tumor necrosis factor alpha modulates the dynamics of the plasminogen-mediated early interaction between Bifidobacterium animalis subsp. lactis and human enterocytes. [O] . Centanni, Manuela, Bergmann, Simone, Turroni, Silvia, 2012

机译：肿瘤坏死因子α调节动物双歧杆菌亚种之间纤溶酶原介导的早期相互作用的动力学。乳酸和人类肠上皮细胞。
8. Interdependence of the Radioprotective Effects of Human Recombinant Interleukin 1alpha, Tumor Necrosis Factor alpha, Granulocyte Colony-Stimulating Factor, and Murine Recombinant Granulocyte-Macrophage Colony-Stimulating Factor [R] . Neta, R., Oppenheim, J. J., Douches, S. D. 1988

机译：人重组白细胞介素1α，肿瘤坏死因子α，粒细胞集落刺激因子和小鼠重组粒细胞 - 巨噬细胞集落刺激因子的辐射保护作用的相互依赖性

Tumor Necrosis Factor Alpha Modulates the Dynamics of the Plasminogen-Mediated Early Interaction between Bifidobacterium animalis subsp. lactis and Human Enterocytes

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