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首页> 外文期刊>Applied Microbiology >Effects of a Systemic Antibiotic on Nasal Bacterial Ecology in Man
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Effects of a Systemic Antibiotic on Nasal Bacterial Ecology in Man

机译：系统性抗生素对人鼻细菌生态的影响

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The nasal flora of coagulase-positive staphylococcus carriers and noncarriers was studied in aerobic conditions in 17 individuals. Five hundred milligrams of cephalexin was given orally four times daily for 12 days, and its effects on the nasal bacteria were determined quantitatively before, during, and after treatment. The total count obtained before the drug treatment was 5.4 × 106 in carriers and 3.9 × 106 in noncarriers. The lowest total count observed was 3 days after the cessation of the drug. The increase in gram-negative rods was seen 9 days after antibiotic therapy, not during the greatest reduction of gram-positive bacteria. Coagulase-positive cocci and diphtheroids were most sensitive to drug treatment. After 36 days, the total count was restored to pretreatment level. Diphtheroids did not return to the original number and were replaced by a corresponding increase of resistant coagulase-negative cocci. An inverse relationship between coagulase-negative cocci and lipophilic diphtheroids was seen in the anterior nares of many individuals. No gross difference in nasal ecology to differentiate carriers from noncarriers was seen.
机译：在有氧条件下研究了凝固酶阳性葡萄球菌携带者和非携带者的鼻部菌群，共有17个人。每天四次口服500毫克的头孢氨苄，共12天，并在治疗前，治疗中和治疗后定量测定其对鼻细菌的作用。药物治疗前携带者的总计数为5.4×106，非携带者为3.9×106。观察到的最低总计数是停药后3天。抗生素治疗后第9天，革兰氏阴性菌的数量增加，而革兰氏阳性菌的减少幅度最大。凝固酶阳性球菌和双环类药物对药物治疗最敏感。 36天后，总数恢复到治疗前水平。蝶形虫没有恢复到原来的数量，而是被相应增加的抗凝酶阴性球菌所取代。在许多人的前鼻孔中观察到凝固酶阴性球菌与亲脂性双环螺旋菌之间存在反比关系。鼻生态学上没有明显差异可以区分携带者和非携带者。

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