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首页> 外文期刊>Applied Microbiology >Susceptibility of Recent Isolates of Pseudomonas aeruginosa to Gentamicin, Polymyxin, and Five Penicillins, with Observations on the Pyocin and Immunotypes of the Strains
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Susceptibility of Recent Isolates of Pseudomonas aeruginosa to Gentamicin, Polymyxin, and Five Penicillins, with Observations on the Pyocin and Immunotypes of the Strains

机译：近期铜绿假单胞菌分离株对庆大霉素，多粘菌素和五种青霉素的敏感性以及菌株的霉素和免疫型观察

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摘要

The susceptibilities of recently isolated strains of Pseudomonas aeruginosa to gentamicin, polymyxin B, carbenicillin, ampicillin, penicillin G, and two newer penicillins were tested with the inocula-replicating technique by using undiluted and 10?3 dilutions of the cultures. With either inoculum, polymyxin B was the most active agent, and a comparison with previous data from this laboratory showed that the susceptibility of P. aeruginosa to this antibiotic had not changed over the past 20 years. Gentamicin was nearly as active as polymyxin, all but 2 of the 141 strains tested with the diluted inoculum being inhibited by 6.25 μg/ml or less. AB-2288, an agent resembling carbenicillin, was four times more active than carbenicillin or BLP-1654; the last two were equally active against the 10?3 inoculum. A more marked inoculum effect was noted with the penicillin analogues tested, the increase in minimum inhibiting concentration with the undiluted culture being eight-fold for carbenicillin and at least 16-fold for AB-2288 and BLP-1654. Pyocin typing and serotyping failed to demonstrate any clearly predominating types.
机译：使用接种复制技术，使用未经稀释的培养液和10？3稀释液，对最近分离出的铜绿假单胞菌菌株对庆大霉素，多粘菌素B，羧苄青霉素，氨苄青霉素，青霉素G和两种较新的青霉素的敏感性进行了测试。无论使用哪种接种物，多粘菌素B都是最活跃的药物，与该实验室先前的数据比较表明，铜绿假单胞菌对这种抗生素的敏感性在过去20年中没有改变。庆大霉素的活性几乎与多粘菌素一样，除稀释接种物外，测试的141株菌株中除2株均抑制了6.25μg/ ml或更低。类似于羧苄青霉素的药物AB-2288的活性是羧苄青霉素或BLP-1654的四倍;后两个对10？3接种物同样活跃。用测试的青霉素类似物观察到了更明显的接种效果，未稀释培养物中最小抑制浓度的增加对羧苄青霉素是八倍，对于AB-2288和BLP-1654至少是十六倍。霉素的分型和血清分型未能显示出任何明显占优势的类型。

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