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首页> 外文期刊>Applied Microbiology >Prevention of the Emergence of Drug Resistance in Bacteria by Acridines, Phenothiazines, and Dibenzocycloheptenes
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Prevention of the Emergence of Drug Resistance in Bacteria by Acridines, Phenothiazines, and Dibenzocycloheptenes

机译：通过cr啶，吩噻嗪和二苯并环庚烯防止细菌出现耐药性

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It has been found that, like Atabrine, the phenothiazine tranquilizers promazine, chlorpromazine, promethazine, levopromethazine, and Stelazine; the antidepressants (dibenz-azepine and dibenzocycloheptene derivatives) Tofranil, Pertofrane, cyclobenzaprine, Elavil, protriptyline, and 3-chlorodibenzocycloheptene; and the acridine derivatives acridine orange, acriflavin, SKF no. 16214-A2, SKF no. 13231-A2, SKF no. 9200, and SKF no. 9836 are all to a greater or lesser extent than Atabrine, effective in preventing the emergence of resistant strains of Staphylococcus aureus and Escherichia coli in the presence of streptomycin, sulfathiazole, or chloramphenicol. The antimalarials chloroquine and hydroxychloroquine were also studied and found to be ineffective. The medical significance of these findings is discussed, as well as the effect of the structural variations of these compounds on their relative activities.
机译：已经发现，与阿塔布林一样，吩噻嗪镇定剂丙嗪，氯丙嗪，异丙嗪，左旋异丙嗪和司他嗪。抗抑郁药（二苯并ze庚因和二苯并环庚烯衍生物）Tofranil，Pertofrane，环苯扎林，Elavil，普鲁替林和3-氯二苯并环庚烯;和cr啶衍生物derivatives啶橙，a啶黄，SKF No. 16214-A2，SKF号13231-A2，SKF号9200和SKF号9836都比阿塔布林更大或更小，在链霉素，磺胺噻唑或氯霉素存在下，可有效预防金黄色葡萄球菌和大肠杆菌的耐药菌株的出现。还研究了抗疟疾药氯喹和羟氯喹无效。讨论了这些发现的医学意义，以及这些化合物的结构变化对其相对活性的影响。

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