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首页> 外文期刊>Applied Microbiology >Specific Midgut Region Controlling the Symbiont Population in an Insect-Microbe Gut Symbiotic Association
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Specific Midgut Region Controlling the Symbiont Population in an Insect-Microbe Gut Symbiotic Association

机译：控制昆虫-肠道共生共生体中共生体种群的特定中肠区域

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Many insects possess symbiotic bacteria that affect the biology of the host. The level of the symbiont population in the host is a pivotal factor that modulates the biological outcome of the symbiotic association. Hence, the symbiont population should be maintained at a proper level by the host's control mechanisms. Several mechanisms for controlling intracellular symbionts of insects have been reported, while mechanisms for controlling extracellular gut symbionts of insects are poorly understood. The bean bug Riptortus pedestris harbors a betaproteobacterial extracellular symbiont of the genus Burkholderia in the midgut symbiotic organ designated the M4 region. We found that the M4B region, which is directly connected to the M4 region, also harbors Burkholderia symbiont cells, but the symbionts therein are mostly dead. A series of experiments demonstrated that the M4B region exhibits antimicrobial activity, and the antimicrobial activity is specifically potent against the Burkholderia symbiont but not the cultured Burkholderia and other bacteria. The antimicrobial activity of the M4B region was detected in symbiotic host insects, reaching its highest point at the fifth instar, but not in aposymbiotic host insects, which suggests the possibility of symbiont-mediated induction of the antimicrobial activity. This antimicrobial activity was not associated with upregulation of antimicrobial peptides of the host. Based on these results, we propose that the M4B region is a specialized gut region of R. pedestris that plays a critical role in controlling the population of the Burkholderia gut symbiont. The molecular basis of the antimicrobial activity is of great interest and deserves future study.
机译：许多昆虫拥有影响宿主生物学的共生细菌。宿主中共生菌种群的水平是调节共生关联的生物学结果的关键因素。因此，应通过宿主的控制机制将共生种群维持在适当的水平。已经报道了控制昆虫的细胞内共生体的几种机制，而对于控制昆虫的细胞外肠道共生体的机制知之甚少。豆虫Riptortus pedestris在中肠共生器官中的M4区带有伯克霍尔德氏菌属的β变形杆菌细菌细胞外共生体。我们发现，直接连接到M4区的M4B区也包含伯克霍尔德菌共生细胞，但其中的共生菌大部分已死亡。一系列实验表明，M4B区域具有抗菌活性，并且该抗菌活性对Burkholderia共生菌特别有效，但对培养的Burkholderia和其他细菌无效。在共生宿主昆虫中检测到M4B区的抗菌活性，在第五龄期达到最高点，而在无共生宿主昆虫中未检测到，这表明了由共生体介导的抗菌活性诱导的可能性。该抗微生物活性与宿主的抗微生物肽的上调无关。基于这些结果，我们建议M4B地区是pedestris的一个特殊的肠道区域，在控制Burkholderia肠道共生菌的种群中起关键作用。抗菌活性的分子基础备受关注，值得进一步研究。

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