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首页> 外文期刊>Applied Microbiology >Toxicity to Rats of Corn Invaded by Chaetomium globosum
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Toxicity to Rats of Corn Invaded by Chaetomium globosum

机译：球壳拟南杆菌对玉米大鼠的毒性

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Of 53 isolates of Chaetomium globosum Kunze isolated from corn, manufactured feed, and fiberboard, grown on autoclaved corn, and fed to rats, 25 were lethal within 4 to 6 days. Thirty-six single ascospore cultures of one isolate were uniformly lethal when similarly grown and fed to rats. Incubation of the fungus on corn for 6 to 8 weeks resulted in greater toxicity than shorter incubation times. Premortem symptoms indicated damage to the central nervous system of the affected animals, and postmortem lesions included hemoglobinuria, hemorrhagic enteritis, and subdural hemorrhaging. Corn invaded by C. globosum and toxic to rats had no detectable effects on swine when fed as their sole ration for 6 weeks, and appeared to be consumed with relish. The toxic substance was best obtained by defatting the fungus-invaded corn with petroleum ether (bp, 60 to 70 C), extraction with acetone, and further purification by elution from a silica gel column with acetone and 5% acetone in chloroform.
机译：从玉米，人工饲料和纤维板中分离出的53株球毛拟南芥分离株，在高压灭菌的玉米上生长并饲喂给大鼠，其中25株在4至6天内致死。一种分离株的36种单一子囊孢子培养物在相似生长并喂食大鼠时均具有相同的致死性。与较短的孵育时间相比，将真菌在玉米上孵育6至8周可产生更大的毒性。死前症状表明受影响动物的中枢神经系统受损，死后病变包括血红蛋白尿，出血性肠炎和硬膜下出血。单独喂食6周后，被球孢梭菌侵袭并对大鼠有毒的玉米对猪没有可检测到的作用，并且看起来很美味。通过用石油醚（沸点为60至70℃）使侵害真菌的玉米脱脂，用丙酮萃取，再通过从硅胶柱上用丙酮和5％丙酮的氯仿溶液洗脱进行纯化，可以最好地获得有毒物质。

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