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Antagonistic Effect on Clostridium botulinum Type E by Organisms Resembling It

机译：与其相似的生物对E型肉毒梭菌的拮抗作用

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摘要

A bacteriocin-like substance, active against strains of Clostridium botulinum type E, is produced by certain nontoxic organisms whose biochemical properties and morphological characteristics are similar to type E. The substance, for which the name “boticin E” is proposed, is bacteriolytic for vegetative cells and bacteriostatic for spores of type E. Its spectrum of activity is somewhat strain-specific. Of the clostridial species tested, only C. botulinum type E and, to a lesser extent, C. perfringens and C. acetobutylicum, but not C. botulinum types A, B, or F, are sensitive. Irreversibly resistant variants originating from both vegetative cells and spores of certain strains were obtained. The active substance is heat-stable and dialyzable, and is not inactivated by chloroform but is digested by trypsin. Ethyl alcohol and acetone precipitates are fully active, whereas trichloroacetic acid precipitates are only partially active. Other nontoxic organisms producing similar antagonistic substances are discussed.
机译：某些对E型肉毒梭菌具有活性的细菌素样物质，是由某些无毒生物产生的，其生物化学特性和形态特征与E型相似。提议将其命名为“ Boticin E”的物质具有杀菌作用。营养细胞和E型孢子的抑菌剂。其活性谱在某种程度上是菌株特异性的。在所测试的梭菌物种中，只有E型肉毒梭菌和较小程度的产气荚膜梭菌和丙酮丁醇梭菌对A，B或F型肉毒梭菌敏感。获得了来自某些菌株的营养细胞和孢子的不可逆抗性变体。活性物质是热稳定的和可透析的，并且不会被氯仿灭活，但是会被胰蛋白酶消化。乙醇和丙酮沉淀物具有完全活性，而三氯乙酸沉淀物仅具有部分活性。讨论了产生类似拮抗物质的其他无毒生物。

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