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Enhancement of Friend Leukemia Virus Infection in Mice by Guaroa Virus: Quantitation and Action of Various Oncogenic and Nononcogenic Viruses

机译:Guaroa病毒增强小鼠白血病病毒感染的可能性:各种致癌和非致癌病毒的定量和作用

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Previous studies have indicated that Guaroa virus (GV), an arbovirus, enhanced the replication of Friend leukemia virus (FLV) in mice. To study further the interaction of GV and FLV, different levels of FLV activity were inoculated into mice. At a level of activity capable of producing limited splenic response, coinfection with GV resulted in a marked increase in spleen-foci activity, mean spleen weight, and amount of infectious virus recoverable from plasma and spleen of dually infected mice. Various oncogenic and nononcogenic viruses were also tested for their ability to enhance FLV infection.
机译:先前的研究表明,虫媒病毒Guaroa病毒(GV)在小鼠中增强了Friend白血病病毒(FLV)的复制。为了进一步研究GV和FLV的相互作用,将不同水平的FLV活性接种到小鼠中。在能够产生有限的脾反应的活性水平下,GV合并感染导致脾灶活性,平均脾脏重量和可从血浆和脾脏中双重感染小鼠中恢复的传染性病毒数量显着增加。还测试了各种致癌和非致癌病毒增强FLV感染的能力。

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