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首页> 外文期刊>Applied Microbiology >Exceptional Production of both Prodigiosin and Cycloprodigiosin as Major Metabolic Constituents by a Novel Marine Bacterium, Zooshikella rubidus S1-1
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Exceptional Production of both Prodigiosin and Cycloprodigiosin as Major Metabolic Constituents by a Novel Marine Bacterium, Zooshikella rubidus S1-1

机译：新型海洋细菌Zooshikella rubidus S1-1出色地生产了Prodigiosin和Cycloprodigiosin作为主要的代谢成分。

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A Gram-negative, red-pigment-producing marine bacterial strain, designated S1-1, was isolated from the tidal flat sediment of the Yellow Sea, Korea. On the basis of phenotypic, phylogenetic, and genetic data, strain S1-1 (KCTC 11448BP) represented a new species of the genus Zooshikella . Thus, we propose the name Zooshikella rubidus sp. nov. Liquid chromatography and mass spectrometry of the red pigments produced by strain S1-1 revealed that the major metabolic compounds were prodigiosin and cycloprodigiosin. In addition, this organism produced six minor prodigiosin analogues, including two new structures that were previously unknown. To our knowledge, this is the first description of a microorganism that simultaneously produces prodigiosin and cycloprodigiosin as two major metabolites. Both prodigiosin and cycloprodigiosin showed antimicrobial activity against several microbial species. These bacteria were approximately 1.5-fold more sensitive to cycloprodigiosin than to prodigiosin. The metabolites also showed anticancer activity against human melanoma cells, which showed significantly more sensitivity to prodigiosin than to cycloprodigiosin. The secondary metabolite profiles of strain S1-1 and two reference bacterial strains were compared by liquid chromatography-mass spectrometry. Multivariate statistical analyses based on secondary metabolite profiles by liquid chromatography-mass spectrometry indicated that the metabolite profile of strain S1-1 could clearly be distinguished from those of two phylogenetically related, prodigiosin-producing bacterial strains.
机译：从韩国黄海的潮滩沉积物中分离出了革兰氏阴性，产生红色色素的海洋细菌菌株，命名为S1-1。根据表型，系统发育和遗传数据，菌株S1-1（KCTC 11448BP）代表了Zooshikella属的一个新物种。因此，我们建议使用名字Zooshikella rubidus sp。十一月菌株S1-1产生的红色颜料的液相色谱和质谱分析表明，主要的代谢化合物是prodigiosin和cycloprodigiosin。此外，该生物体还产生了6种次要的prodigiosin类似物，包括两个以前未知的新结构。就我们所知，这是同时产生prodigiosin和cycloprodigiosin作为两种主要代谢产物的微生物的首次描述。 prodigiosin和cycloprodigiosin均显示出对几种微生物的抗菌活性。这些细菌对环prodigiosin的敏感性大约是对prodigiosin的1.5倍。代谢物还显示出对人黑素瘤细胞的抗癌活性，对黑素瘤细胞的敏感性比对环粉菌灵的敏感性高得多。通过液相色谱-质谱法比较了菌株S1-1和两个参考细菌菌株的次级代谢产物谱。基于液相色谱-质谱法基于二级代谢产物谱的多变量统计分析表明，菌株S1-1的代谢产物谱可与两种系统发育相关的产前靛蓝素的细菌菌株明显区别。

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