Conserved Mechanisms of Mycobacterium marinum Pathogenesis within the Environmental Amoeba Acanthamoeba castellanii

George M. Kennedy; J. Hiroshi Morisaki; Patricia A. DiGiuseppe Champion

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Conserved Mechanisms of Mycobacterium marinum Pathogenesis within the Environmental Amoeba Acanthamoeba castellanii

机译：环境变形虫变形虫中海藻分枝杆菌致病机制的保守机制

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Mycobacterium marinum is a waterborne mycobacterial pathogen. Due to their common niche, protozoa likely represent natural hosts for M. marinum . We demonstrate that the ESX-1 secretion system is required for M. marinum pathogenesis and that M. marinum utilizes actin-based motility in amoebae. Therefore, at least two virulence pathways used by M. marinum in macrophages are conserved during M. marinum infection of amoebae.

机译：海水分枝杆菌是一种水生分枝杆菌病原体。由于它们共同的生态位，原生动物很可能代表了海洋分枝杆菌的天然宿主。我们证明，ESX-1分泌系统是海藻分支杆菌发病机理所必需的，海藻分支杆菌利用变形虫中基于肌动蛋白的运动。因此，在变形虫的海藻支原体感染期间，海藻支原体在巨噬细胞中使用的至少两种毒力途径得以保留。

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《Applied Microbiology》 |2012年第6期|共4页
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George M. Kennedy; J. Hiroshi Morisaki; Patricia A. DiGiuseppe Champion;
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6. Conserved Mechanisms of Mycobacterium marinum Pathogenesis within the Environmental Amoeba Acanthamoeba castellanii [O] . George M. Kennedy, J. Hiroshi Morisaki, Patricia A. DiGiuseppe Champion 2012

机译：环境变形虫变形虫中海藻分枝杆菌致病机理的保守机制
7. Conserved Mechanisms of Mycobacterium marinum Pathogenesis within the Environmental Amoeba Acanthamoeba castellanii [O] . George M. Kennedy, J. Hiroshi Morisaki, Patricia A. DiGiuseppe Champion 2012

机译：环境Amoeba Acanthamoeba Castellanii内的分枝杆菌病发生的保守机制

Conserved Mechanisms of Mycobacterium marinum Pathogenesis within the Environmental Amoeba Acanthamoeba castellanii

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