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Bifidobacterial Succession and Correlation Networks in a Large Unselected Cohort of Mothers and Their Children

机译：大量未选定的母亲及其子女群体中的双歧杆菌继承和相关网络

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Bifidobacteria are a major microbial component of infant gut microbiota, which is believed to promote health benefits for the host and stimulate maturation of the immune system. Despite their perceived importance, very little is known about the natural development of and possible correlations between bifidobacteria in human populations. To address this knowledge gap, we analyzed stool samples from a randomly selected healthy cohort of 87 infants and their mothers with >90% of vaginal delivery and nearly 100% breast-feeding at 4 months. Fecal material was sampled during pregnancy, at 3 and 10 days, at 4 months, and at 1 and 2 years after birth. Stool samples were predicted to be rich in the species Bifidobacterium adolescentis , B. bifidum , B. dentium , B. breve , and B. longum . Due to high variation, we did not identify a clear age-related structure at the individual level. Within the population as a whole, however, there were clear age-related successions. Negative correlations between the B. longum group and B. adolescentis were detected in adults and in 1- and 2-year-old children, whereas negative correlations between B. longum and B. breve were characteristic for newborns and 4-month-old infants. The highly structured age-related development of and correlation networks between bifidobacterial species during the first 2 years of life mirrors their different or competing nutritional requirements, which in turn may be associated with specific biological functions in the development of healthy gut.
机译：双歧杆菌是婴儿肠道菌群的主要微生物成分，据信可促进宿主的健康，并刺激免疫系统的成熟。尽管它们具有重要性，但人们对双歧杆菌的自然发育及其之间可能的相关关系知之甚少。为了解决这一知识鸿沟，我们分析了来自87个婴儿及其母亲的随机选择的健康队列中的粪便样本，其中4个月时阴道分娩率超过90％，母乳喂养率接近100％。在怀孕期间，出生后3天和10天，4个月以及1年和2年对粪便进行采样。粪便标本预计富含青春双歧杆菌，双歧双歧杆菌，齿状芽孢杆菌，短芽孢杆菌和长双歧杆菌。由于差异很大，因此我们没有在个人层面确定清晰的年龄相关结构。但是，在整个人口中，存在明显的与年龄有关的继承。在成年人以及1岁和2岁儿童中，长双歧杆菌组与青春双歧杆菌之间呈负相关，而新生儿和4个月大婴儿的特征在于长双歧杆菌和短双歧杆菌之间呈负相关。 。双歧杆菌物种在生命的前两年高度结构化的与年龄相关的发育和相互之间的关联网络反映了它们不同或竞争性的营养需求，这又可能与健康肠道发育中的特定生物学功能有关。

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