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首页> 外文期刊>Applied Microbiology >The CasKR Two-Component System Is Required for the Growth of Mesophilic and Psychrotolerant Bacillus cereus Strains at Low Temperatures
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The CasKR Two-Component System Is Required for the Growth of Mesophilic and Psychrotolerant Bacillus cereus Strains at Low Temperatures

机译：低温下嗜温和耐精神蜡状芽孢杆菌菌株的生长需要CasKR两组分系统

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摘要

The different strains of Bacillus cereus can grow at temperatures covering a very diverse range. Some B. cereus strains can grow in chilled food and consequently cause food poisoning. We have identified a new sensor/regulator mechanism involved in low-temperature B. cereus growth. Construction of a mutant of this two-component system enabled us to show that this system, called CasKR, is required for growth at the minimal temperature ( T _(min)). CasKR was also involved in optimal cold growth above T _(min) and in cell survival below T _(min). Microscopic observation showed that CasKR plays a key role in cell shape during cold growth. Introducing the casKR genes in a Δ casKR mutant restored its ability to grow at T _(min). Although it was first identified in the ATCC 14579 model strain, this mechanism has been conserved in most strains of the B. cereus group. We show that the role of CasKR in cold growth is similar in other B. cereus sensu lato strains with different growth temperature ranges, including psychrotolerant strains.
机译：蜡状芽孢杆菌的不同菌株可以在涵盖非常不同范围的温度下生长。一些蜡状芽孢杆菌菌株可以在冷藏食品中生长，并因此导致食品中毒。我们已经确定了一种与低温蜡状芽孢杆菌生长有关的新传感器/调节器机制。这种两组分系统突变体的构建使我们能够证明，这个名为CasKR的系统是在最低温度（T _（min））下生长所必需的。 CasKR还参与了T_（min）以上的最佳冷生长和T_（min）以下的细胞存活。显微镜观察表明，CasKR在冷生长过程中对细胞形状起关键作用。在ΔcasKR突变体中引入casKR基因可恢复其在T_（min）生长的能力。尽管它是在ATCC 14579模型菌株中首次发现的，但该机制在蜡状芽孢杆菌组的大多数菌株中都得到了保留。我们表明，CasKR在寒冷生长中的作用在其他具有不同生长温度范围的蜡状芽孢杆菌中也很相似，包括抗精神病病毒株。

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