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Alpha Sarcin, a New Antitumor Agent II. Fermentation and Antitumor Spectrum

机译：新型抗肿瘤药物II Alpha Sarcin。发酵和抗肿瘤谱

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Aspergillus giganteus MDH 18894 was found to produce alpha sarcin, a new antitumor agent inhibitory to a number of different animal tumors. This culture produced culture filtrates that inhibited mouse sarcoma 180 at dilutions up to 1:32. Optimal fermentation conditions were established for shake flasks and 30-liter and 100-gal (378.5-liter) fermentors. Results from a variety of media were reported; however, the medium which yielded the most reproducible filtrates consisted of 2% corn starch, 1.5% beef extract (Difco), 2% peptone (Difco), and 0.5% sodium chloride. Purified preparations of 800 sarcoma 180 dilution units per mg were inactive against bacteria, yeasts, molds, actinomycetes, and protozoa, but were cytotoxic to several strains of mammalian cells. Alpha sarcin inhibited sarcoma 180 in mice at a dose of 62.5 μg per kg per day. A variety of other animal tumors were also inhibited by this compound.
机译：发现大曲霉MDH 18894产生αsarcin，αsarcin是一种抑制许多不同动物肿瘤的新型抗肿瘤剂。该培养物产生的培养物滤液以高达1:32的比例抑制小鼠肉瘤180。确定了摇瓶，30升和100加仑（378.5升）发酵罐的最佳发酵条件。报告了各种媒体的结果;但是，产生最多可重复性滤液的培养基包括2％的玉米淀粉，1.5％的牛肉提取物（Difco），2％的蛋白ept（Difco）和0.5％的氯化钠。每毫克800个肉瘤180稀释单位的纯化制剂对细菌，酵母，霉菌，放线菌和原生动物无活性，但对几种哺乳动物细胞株具有细胞毒性。 Alpha sarcin以每天每公斤62.5μg的剂量抑制小鼠的肉瘤180。该化合物还抑制了多种其他动物肿瘤。

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