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首页> 外文期刊>Applied Microbiology >Absence of 5-Hydroxy-4-Ketohexanoate and the α-Ketoglutarate Dehydrogenase Complex in Mutants of Saccharomyces oviformis Incapable of Growing on Ethanol
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Absence of 5-Hydroxy-4-Ketohexanoate and the α-Ketoglutarate Dehydrogenase Complex in Mutants of Saccharomyces oviformis Incapable of Growing on Ethanol

机译：无法在乙醇上生长的酿酒酵母突变体中没有5-羟基-4-酮己酸和α-酮戊二酸脱氢酶复合物

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摘要

The roles of the enzyme which forms 5-hydroxy-4-ketohexanoate (HKH) and of related enzymes in the metabolism of ethanol were studied in Saccharomyces oviformis WH92 and its mutants, which grew poorly or not at all on ethanol. The strains, which did not grow on ethanol, did not form HKH from α-ketoglutarate and acetaldehyde enzymatically and were also devoid of the α-ketoglutarate dehydrogenase complex. Acetaldehyde inhibited the activity of α-ketoglutarate dehydrogenase. These mutants did not grow on acetate since they had no acetyl-CoA synthetase activity. The relationship of the formation of HKH with the metabolism of ethanol is discussed.
机译：在产酿酒酵母WH92及其突变体中研究了形成5-羟基-4-酮己酸酯（HKH）的酶和相关酶在乙醇代谢中的作用，该突变体在乙醇中生长差或根本不生长。不能在乙醇上生长的菌株不能通过酶法由α-酮戊二酸和乙醛形成HKH，并且也没有α-酮戊二酸脱氢酶复合物。乙醛抑制α-酮戊二酸脱氢酶的活性。这些突变体没有在乙酸盐上生长，因为它们没有乙酰辅酶A合成酶活性。讨论了HKH的形成与乙醇代谢的关系。

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