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首页> 外文期刊>Applied Microbiology >Antiviral Activity of a bis-Benzimidazole Against Experimental Rhinovirus Infections in Chimpanzees
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Antiviral Activity of a bis-Benzimidazole Against Experimental Rhinovirus Infections in Chimpanzees

机译：双苯并咪唑对黑猩猩实验性鼻病毒感染的抗病毒活性。

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The marked antiviral activity of (S,S-1,2-bis(5-methoxy-2-benzimidazolyl)-1,2-ethanediol (Abbott 36683) against rhinoviruses in tissue culture warranted investigation of its antiviral activity in vivo. Antiviral levels in mouse sera were attained with an oral dose as small as 10 mg/kg and detectable antiviral levels of drug were also found in lung, liver, kidney, intestinal contents, and urine of mice given a single 300 mg/kg oral dose. Antiviral serum levels were also obtained when monkeys were given a single oral dose of Abbott 36683. Six chimpanzees were infected with 100 median tissue culture infective dose units (TCID50) of rhinovirus 30. Three of the animals were treated with Abbott 36683, 100 mg/kg daily for 4 consecutive days. Virus shedding occurred in the infected controls but could not be demonstrated in the treated animals from postinfection days 1 to 8. Two of the treated animals did, however, shed virus on day 9. The compound was retested in chimpanzees at dosage levels of 15 and 50 mg/kg daily for 4 days. Each animal was challenged with 100 TCID50 of rhinovirus 49. Partial protection was obtained. In a third trial, a single 100 mg/kg dose of the compound was administered to chimpanzees infected with rhinovirus 44. Virus was isolated from all throat smears taken from treated animals, indicating that at the lowest drug level no protection occurred.
机译：在组织培养中，（S，S-1,2-双（5-甲氧基-2-苯并咪唑基）-1,2-乙二醇（Abbott 36683）对鼻病毒具有显着的抗病毒活性，因此有必要对其体内的抗病毒活性进行研究。口服剂量为300 mg / kg的小鼠，口服剂量低至10 mg / kg，在小鼠的肺，肝，肾，肠内容物和尿液中也发现了可检测到的抗病毒药物水平。当给猴子单次口服雅培36683时也获得了血清水平。六只黑猩猩感染了100个鼻病毒30组织培养感染剂量中位数（TCID50）。三只动物接受了100 mg / kg的雅培36683治疗每天连续4天，在受感染的对照组中发生病毒脱落，但从感染后第1天到第8天在被治疗的动物中未表现出病毒。但是，有两只被治疗的动物在第9天就脱落了病毒。在黑猩猩中对化合物进行了重新测试。在剂量水平o f 15和50 mg / kg每天，持续4天。用100 TCID50的鼻病毒49攻击每只动物。获得了部分保护。在第三项试验中，对感染了鼻病毒44的黑猩猩施用了100 mg / kg的单剂量化合物。从治疗动物的所有喉部涂片中分离出病毒，表明在最低药物水平下没有发生保护作用。

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