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Microbial Formation of Nitrosamines In Vitro

机译:亚硝胺体外微生物形成

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Mortierella parvispora and an unidentified bacterium converted trimethylamine to dimethylamine, and the bacterium (but not the fungus) formed dimethylnitrosamine in the presence of nitrite. Dimethylnitrosamine also appeared in cell suspensions of Escherichia coli and Streptococcus epidermidis and in hyphal mats of Aspergillus oryzae incubated with dimethylamine and nitrate. Suspensions of a number of microorganisms produced N-nitrosodiphenylamine from diphenylamine and nitrite at pH 7.5, and soluble enzymes catalyzing the N-nitrosation of diphenylamine were obtained from two of these organisms. In the presence of these enzymes, several dialkylamines were converted to the corresponding N-nitroso compounds.
机译:细孢Mortierella parvispora和一个未知细菌将三甲胺转化为二甲胺,细菌(但不是真菌)在亚硝酸盐存在下形成了二甲基亚硝胺。二甲基亚硝胺也出现在大肠杆菌和表皮链球菌的细胞悬液中以及与二甲胺和硝酸盐一起孵育的米曲霉菌丝垫中。多种微生物的悬浮液由二苯胺和亚硝酸盐在pH 7.5下生成N-亚硝基二苯胺,并且从其中两种生物中获得了可催化二苯胺N-亚硝化的酶。在这些酶的存在下,几种二烷基胺被转化为相应的N-亚硝基化合物。

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