Identification of Gold Nanoparticle-Resistant Mutants of Saccharomyces cerevisiae Suggests a Role for Respiratory Metabolism in Mediating Toxicity

Mark R. Smith; Matthew G. Boenzli; Vihangi Hindagolla; Jun Ding; John M. Miller; James E. Hutchison; Jeffrey A. Greenwood; Hagai Abeliovich; Alan T. Bakalinsky

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Identification of Gold Nanoparticle-Resistant Mutants of Saccharomyces cerevisiae Suggests a Role for Respiratory Metabolism in Mediating Toxicity

机译：酿酒酵母的金纳米粒子抗性突变体的鉴定表明呼吸代谢在介导毒性中的作用。

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Positively charged gold nanoparticles (0.8-nm core diameter) reduced yeast survival, but not growth, at a concentration of 10 to 100 μg/ml. Among 17 resistant deletion mutants isolated in a genome-wide screen, highly significant enrichment was observed for respiration-deficient mutants lacking genes encoding proteins associated with the mitochondrion.

机译：带正电的金纳米颗粒（核心直径为0.8-nm）在10至100μg/ ml的浓度下会降低酵母菌的存活率，但不会降低其生长。在全基因组筛选中分离出的17个抗性缺失突变体中，观察到呼吸缺乏突变体的高度显着富集，这些突变体缺少编码与线粒体相关蛋白的基因。

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《Applied Microbiology》 |2013年第2期|共6页
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Mark R. Smith; Matthew G. Boenzli; Vihangi Hindagolla; Jun Ding; John M. Miller; James E. Hutchison; Jeffrey A. Greenwood; Hagai Abeliovich; Alan T. Bakalinsky;
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1. RNA-Seq analysis of global transcriptomic changes suggests a roles for the MAPK pathway and carbon metabolism in cell wall maintenance in a Saccharomyces cerevisiae FKS1 mutant [J] . Huang Cong, Zhao Fengguang, Lin Ying, Biochemical and Biophysical Research Communications . 2018,第3期

机译：RNA-SEQ全局转录组变化的分析表明，Mapk途径和碳代谢在酿酒酵母中的酿酒酵母中的Cell壁维持中的作用
2. Analysis of Polygenic Mutants Suggests a Role for Mediator in Regulating Transcriptional Activation Distance in Saccharomyces cerevisiae [J] . Reavey Caitlin T., Hickman Mark J., Dobi Krista C., Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 2015,第2期

机译：多基因突变体的分析表明，在调节酿酒酵母转录激活距离中介体的作用。
3. Analysis of Polygenic Mutants Suggests a Role for Mediator in Regulating Transcriptional Activation Distance in Saccharomyces cerevisiae [J] . Caitlin T. Reavey, David Botstein, Fred Winston, Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 2015,第2期

机译：多基因突变体的分析表明，在调节酿酒酵母转录激活距离中介体的作用。
4. Polysome-seq as a Measure of Translational Profile from Deoxyhypusine Synthase Mutant in Saccharomyces cerevisiae [C] . Fernanda Manaia Demarqui, Ana Carolina Silva Paiva, Mariana Marchi Santoni, Brazilian Symposium on Bioinformatics . 2020

机译：PolySome-SEQ作为酿酒酵母酿酒酵母中脱氧型血清合酶突变体的转化概况的量度
5. Identification of Novel Mediators of Efficient Non-Homologous End Joining in the Yeast Saccharomyces cerevisiae. [D] . Jessulat, Matthew. 2011

机译：酵母酿酒酵母中高效非同源末端连接的新型介导剂的鉴定。
6. Identification of Gold Nanoparticle-Resistant Mutants of Saccharomyces cerevisiae Suggests a Role for Respiratory Metabolism in Mediating Toxicity [O] . Mark R. Smith, Matthew G. Boenzli, Vihangi Hindagolla, 2013

机译：酿酒酵母的金纳米粒子抗性突变体的鉴定表明呼吸代谢在介导毒性中的作用。
7. Identification of gold nanoparticle-resistant mutants of Saccharomyces cerevisiae suggests a role for respiratory metabolism in mediating toxicity [O] . 2013

机译：酿酒酵母的金纳米粒子抗性突变体的鉴定表明呼吸代谢在介导毒性中的作用
8. TSC (Temperature Sensitive Suppressors of the Calcium Sensitivity of CSG2A) Mutants; A Tool to Investigate Sphingolipid metabolism in the Yeast Saccharomyces Cerevisiae [R] . Slife, H. F. 1998

机译：TsC（CsG2a的钙敏感性的温度敏感抑制剂）突变体;调查酵母酿酒酵母中鞘脂代谢的工具

Identification of Gold Nanoparticle-Resistant Mutants of Saccharomyces cerevisiae Suggests a Role for Respiratory Metabolism in Mediating Toxicity

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