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Articles of Significant Interest Selected from This Issue by the Editors

机译：编辑从本期中精选的重要文章

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Engineering a heterologous acetogenic Wood-Ljungdahl pathway (WLP) in the industrial solventogen Clostridium acetobutylicum would minimize CO2 and H2 release, thereby enabling the conversion of renewable carbohydrates into a broad spectrum of metabolites at higher yields than are currently possible. A key challenge towards that goal is the functional expression of the core WLP enzyme, acetyl coenzyme A (CoA) synthase (ACS), which synthesizes acetyl-CoA from CO and an activated methyl group. Fast and Papoutsakis (e02307-17) adapted the classical in vitro ACS carbonyl-carbon exchange assay to the in vivo setting, thus demonstrating the in vivo function of the heterologous C. ljungdahlii ACS in C. acetobutylicum.
机译：在工业溶剂原丙酮丁醇梭菌中工程化异源产乙酸的伍德-隆杰尔途径（WLP）将使CO2和H2的释放降至最低，从而使可再生碳水化合物以更高的转化率转化为广泛的代谢产物。实现该目标的关键挑战是核心WLP酶乙酰辅酶A（CoA）合酶（ACS）的功能表达，该酶可从CO和活化的甲基合成乙酰辅酶A。 Fast and Papoutsakis（e02307-17）使经典的体外ACS羰基碳交换试验适应体内环境，从而证明了异丁酸梭菌ACS在丙酮丁醇梭菌中的体内功能。

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