Effect on the White Rat Uterus of a Toxic Substance Isolated from Fusarium

C. M. Christensen; G. H. Nelson; C. J. Mirocha

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Effect on the White Rat Uterus of a Toxic Substance Isolated from Fusarium

机译：镰刀菌分离出的有毒物质对白大白鼠子宫的影响

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Eighty-five fungi isolated from prepared feed and from corn collected on farms were grown separately in moist autoclaved corn. The corn was fed to virgin weanling rats for 5 to 12 days; the rats were then killed, and their uteri were removed and weighed. Twelve isolates of Fusarium from corn and one from poinsettias caused increases of five to eight times in weight of the uterus as compared with controls that were fed sound corn. The greatest increase in weight of the uterus was caused by corn inoculated with Fusarium No. 5 incubated for 21 days at 20 to 25 C followed by 14 days at 12 C. Extraction of this corn with methylene chloride, separation into fractions by means of a silicic acid column, and further purification by thin-layer chromatography yielded a compound with ultraviolet-absorption maxima at 314, 274, and 236 mμ.

机译：从制备的饲料和农场收集的玉米中分离出的八十五种真菌分别在高压灭菌的玉米中生长。将玉米喂给初次断奶的大鼠5至12天。然后杀死大鼠，取出子宫并称重。与饲喂纯玉米的对照组相比，从玉米中分离出十二种镰刀菌，从一品红中分离出一株，导致子宫重量增加了五到八倍。子宫重量的最大增加是由于用5号镰刀菌接种的玉米在20至25℃下孵育21天，然后在12℃下孵育14天而引起的。用二氯甲烷萃取该玉米，并通过硅胶分离成级分。硅酸柱，然后通过薄层色谱法进一步纯化，得到在314、274和236mμ处具有最大紫外线吸收的化合物。

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《Applied Microbiology》 |1965年第5期|共7页
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C. M. Christensen; G. H. Nelson; C. J. Mirocha;
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5. Fumonisin B(1) from Fusarium moniliforme culture material varies in toxicity to channel catfish and rats with purity. [D] . Manning, Bruce Benjamin. 1998

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6. Effect on the White Rat Uterus of a Toxic Substance Isolated from Fusarium [O] . C. M. Christensen, G. H. Nelson, C. J. Mirocha 1982

机译：镰刀菌分离的有毒物质对白大白鼠子宫的影响
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机译：含氮杂环，取代（物质a）（星2），含氮杂环，取代（物质B）（星2），含氮杂环，取代（物质C）（星）的大鼠的产前口腔发育毒性研究结果2），含氮杂环，取代（物质D）（星形2）含氮杂环，取代（物质E）（星形2）。

Effect on the White Rat Uterus of a Toxic Substance Isolated from Fusarium

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