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首页> 外文期刊>Applied Microbiology >An Invasive Mammal (the Gray Squirrel, Sciurus carolinensis) Commonly Hosts Diverse and Atypical Genotypes of the Zoonotic Pathogen Borrelia burgdorferiSensu Lato
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An Invasive Mammal (the Gray Squirrel, Sciurus carolinensis) Commonly Hosts Diverse and Atypical Genotypes of the Zoonotic Pathogen Borrelia burgdorferiSensu Lato

机译：侵袭性哺乳动物（灰松鼠，松鼠Carolinensis）通常具有多种人畜共患病病原体伯氏疏螺旋体（Borelia burgdorferiSensu Lato）的基因型和非典型基因型

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Invasive vertebrate species can act as hosts for endemic pathogens and may alter pathogen community composition and dynamics. For the zoonotic pathogen Borrelia burgdorferi sensu lato , the agent of Lyme borreliosis, recent work shows invasive rodent species can be of high epidemiological importance and may support host-specific strains. This study examined the role of gray squirrels ( Sciurus carolinensis ) ( n = 679), an invasive species in the United Kingdom, as B. burgdorferi sensu lato hosts. We found that gray squirrels were frequently infested with Ixodes ricinus , the main vector of B. burgdorferi sensu lato in the United Kingdom, and 11.9% were infected with B. burgdorferi sensu lato . All four genospecies that occur in the United Kingdom were detected in gray squirrels, and unexpectedly, the bird-associated genospecies Borrelia garinii was most common. The second most frequent infection was with Borrelia afzelii . Genotyping of B. garinii and B. afzelii produced no evidence for strains associated with gray squirrels. Generalized linear mixed models (GLMM) identified tick infestation and date of capture as significant factors associated with B. burgdorferi sensu lato infection in gray squirrels, with infection elevated in early summer in squirrels infested with ticks. Invasive gray squirrels appear to become infected with locally circulating strains of B. burgdorferi sensu lato , and further studies are required to determine their role in community disease dynamics. Our findings highlight the fact that the role of introduced host species in B. burgdorferi sensu lato epidemiology can be highly variable and thus difficult to predict.
机译：侵入性脊椎动物可能充当地方病原体的宿主，并可能改变病原体群落组成和动态。对于人畜共患病病原体伯氏疏螺旋体（Borrelia burgdorferi sensu lato），莱姆氏疏螺旋体病的病原体，最近的研究表明，侵入性啮齿动物物种具有很高的流行病学重要性，并可能支持宿主特异性菌株。这项研究研究了灰松鼠（Scuulus carolinensis）（n = 679）（英国入侵种）作为B.burgdorferi sensu lato寄主的作用。我们发现灰松鼠经常感染英国的主要感染伯氏疏螺旋体的蓖麻（Ixodes ricinus）ricinus ricinus，有11.9％感染了感染伯氏疏螺旋体的B. burgdorferi sensu lato。在英国发生的所有四种基因型均在灰松鼠中被检测到，出乎意料的是，与鸟类相关的基因型博雷利亚疏螺旋体是最常见的。第二常见的感染是非洲疏螺旋体。 B. garinii和B. afzelii的基因分型没有发现与灰松鼠有关的菌株的证据。广义线性混合模型（GLMM）将tick虫侵染和捕获日期确定为与灰松鼠burgdorferi sensu lato感染相关的重要因素，夏初感染f虫的松鼠感染升高。入侵的灰松鼠似乎已感染了本地传播的伯氏疏螺旋体，并需要进一步研究以确定它们在社区疾病动态中的作用。我们的发现突出了这样一个事实，即引入的宿主物种在伯氏疏螺旋体流行病学中的作用可能高度可变，因此很难预测。

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