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首页> 外文期刊>Applied Microbiology >PilZ Domain Proteins of the Plant Pathogen Xanthomonas oryzae pv. oryzae Function Differentially in Virulence
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PilZ Domain Proteins of the Plant Pathogen Xanthomonas oryzae pv. oryzae Function Differentially in Virulence

机译:植物病原体黄单胞菌pv的PilZ结构域蛋白。稻瘟病的毒力功能差异

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Cyclic dimeric-GMP (c-di-GMP) is an intracellular signaling molecule implicated in the control of cellular properties that can influence the virulence of pathogens (5, 6). The so-called PilZ domainofcertainproteinscanbindc-di-GMPandtherebyhavea regulatory impact on c-di-GMP-mediated processes (7). The au- thors examined PilZ domain proteins of X. oryzae and demon- strated that two of these proteins, PXO_00049 and PXO_02374, had high binding affinities for c-di-GMP (1). Gene deletions of PXO_00049 or PXO_02374 yielded mutant strains of X. oryzae that displayed increased virulence (1), a finding that is in marked contrast to previous studies with X. oryzae pv. oryzae and other pathogens that have demonstrated that mutation of PilZ domain proteinscandecreasevirulenceunderexperimentalconditions(4, 8, 9). The findings reported by Yang et al. (1) (i) make important contributions to understanding the biology and pathogenesis of X. oryzae pv. oryzae and (ii) provide a basis for future studies designed to develop strategies to control this plant pathogen.
机译:环二聚体GMP(c-di-GMP)是一种细胞内信号分子,与细胞特性的控制有关,可影响病原体的毒性(5,6)。某些蛋白scanbindc-di-GMP的所谓PilZ域,因此对c-di-GMP介导的过程具有调节作用(7)。作者检查了米曲霉的PilZ域蛋白,并证明其中两个蛋白PXO_00049和PXO_02374对c-di-GMP具有高结合亲和力(1)。 PXO_00049或PXO_02374的基因缺失产生了表现出增加的毒力的米曲霉突变株(1),这一发现与以前对米曲霉pv。已经证明PilZ结构域蛋白突变可以在实验条件下降低毒力的稻米和其他病原体(4,8,9)。杨等人报道的发现。 (1)(i)为了解米曲霉PV的生物学和发病机理做出了重要贡献。水稻和(ii)为将来的研究提供基础,这些研究旨在开发控制这种植物病原体的策略。

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