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首页> 外文期刊>Applied Microbiology >Geographical and Temporal Structures of Legionella pneumophila Sequence Types in Comunitat Valenciana (Spain), 1998 to 2013
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Geographical and Temporal Structures of Legionella pneumophila Sequence Types in Comunitat Valenciana (Spain), 1998 to 2013

机译：1998-2013年西班牙瓦伦西亚自治区军团菌嗜肺军团菌序列类型的地理和时间结构

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摘要

Legionella pneumophila is an accidental human pathogen associated with aerosol formation in water-related sources. High recombination rates make Legionella populations genetically diverse, and nearly 2,000 different sequence types (STs) have been described to date for this environmental pathogen. The spatial distribution of STs is extremely heterogeneous, with some variants being present worldwide and others being detected at only a local scale. Similarly, some STs have been associated with disease outbreaks, such as ST578 or ST23. Spain is among the European countries with the highest incidences of reported legionellosis cases, and specifically, Comunitat Valenciana (CV) is the second most affected area in the country. In this work, we aimed at studying the overall diversity of Legionella pneumophila populations found in the period from 1998 to 2013 in 79 localities encompassing 23 regions within CV. To do so, we performed sequence-based typing (SBT) on 1,088 L. pneumophila strains detected in the area from both environmental and clinical sources. A comparison with the genetic structuring detected in a global data set that included 20 European and 7 non-European countries was performed. Our results reveal a level of diversity in CV that can be considered representative of the diversity found in other countries worldwide.
机译：嗜肺军团菌是一种偶然的人类病原体，与水相关源中的气溶胶形成有关。高重组率使军团菌种群具有遗传多样性，迄今为止，已针对该环境病原体描述了近2,000种不同的序列类型（ST）。 ST的空间分布极为不同，全球存在一些变体，而其他变体仅在局部范围内被检测到。同样，一些ST与疾病暴发相关，例如ST578或ST23。西班牙是报告的军团菌病发病率最高的欧洲国家之一，特别是，瓦伦西亚自治区（CV）是该国受影响第二大的地区。在这项工作中，我们旨在研究1998年至2013年期间在CV内23个地区的79个地区发现的嗜肺军团杆菌种群的总体多样性。为此，我们对从环境和临床来源在该地区检测到的1,088株嗜肺乳杆菌进行了基于序列的分型（SBT）。与包括20个欧洲国家和7个非欧洲国家的全球数据集中检测到的遗传结构进行了比较。我们的结果表明，简历的多样性水平可以视为代表了全球其他国家/地区的多样性。

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