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Articles of Significant Interest Selected from This Issue by the Editors

机译:编辑从本期中精选的重要文章

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Diagnosis of foodborne infections currently relies on culture-based methods, which are not rapid enough for real-time disease surveillance and frequently fail to identify the causative agents. Culture-independent metagenomic analyses of stool could overcome these limitations. A study by Huang et al. (e02577-16) represents one of the first efforts to validate the use of metagenomics for outbreak characterization and develop appropriate bioinformatics pipelines for metagenomic data analysis. Metagenomics provided pathogen identification consistent with culture-based analysis for two severe Salmonella outbreaks and, additionally, resolution of the pathogen population and the response of the gut microbiome, which were not attainable by culture-based methods.
机译:食源性感染的诊断目前依靠基于培养的方法,这种方法不够迅速,无法实时监测疾病,并且常常无法确定病原体。粪便的与文化无关的宏基因组学分析可以克服这些限制。黄等人的研究。 (e02577-16)代表了为验证宏基因组学用于暴发特征并开发适当的生物信息学流水线进行宏基因组学数据分析而进行的首批工作之一。元基因组学提供了与两次严重沙门氏菌暴发的基于文化的分析一致的病原体鉴定,此外,还提供了基于文化的方法无法实现的病原体种群解析和肠道微生物组反应。

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