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Articles of Significant Interest Selected from This Issue by the Editors

机译：编辑从本期中精选的重要文章

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Vestimentiferan tubeworms are hosts to intracellular, environmentally acquired, chemolithotrophic gammaproteobacterial symbionts. Phylogenetic analyses based on a few molecular markers seemed to indicate that nearly all of the Eastern Pacific host species were associated with the same symbiont phylotype, Candidatus Endoriftia persephone. Using genome-wide comparisons of Candidatus Endoriftia persephone in association with three worm species, Perez and Juniper (p. 51975205) showed that Northeast Pacific and East Pacific Rise symbiont populations separated by mid-ocean ridge discontinuities were vicariant and that other factors (e.g., local environmental conditions, host specificity) may also shape the genetic makeup of these populations.Novel antimicrobials are critically needed to deal with the current global problems associated with antibiotic resistance in human and animal infections. Using a screening strategy for broad-spectrum antimicrobials combined with genome mining, Ovchinnikov et al. (p. 52165224) discovered a new group of antimicrobial peptides (bacteriocins) that show very potent activity against many important Gram-positive pathogens and their antibiotic-resistant derivatives. These bacteriocins differ from other known bacteriocins in terms of chemical composition and mechanism of action, thus representing great potential in diverse antimicrobial applications. The study also provides a useful strategy to search for novel antimicrobials.
机译：Vestimentiferan块虫是细胞内，环境获得的，化学营养型的γ-蛋白细菌共生体的宿主。基于一些分子标记的系统发育分析似乎表明，几乎所有东太平洋寄主物种都与相同的共生系统型，念珠菌念珠菌有关。 Perez和Juniper（p。51975205）通过将念珠菌Persphone与三种蠕虫联系起来进行全基因组比较，发现东北太平洋和东太平洋上升共生种群被大洋中脊不连续性隔开，这是vicariant，而其他因素（例如，局部环境条件，宿主特异性）也可能影响这些人群的遗传构成。迫切需要新型抗菌素来解决当前与人类和动物感染中的抗生素耐药性相关的全球性问题。 Ovchinnikov等人利用广谱抗菌素的筛选策略结合基因组挖掘。 （p。52165224）发现了一组新的抗菌肽（细菌素），它们对许多重要的革兰氏阳性病原体及其抗药性衍生物具有很强的活性。这些细菌素在化学组成和作用机理方面与其他已知细菌素不同，因此在各种抗菌应用中都具有巨大潜力。该研究还提供了寻找新型抗菌药物的有用策略。

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