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首页> 外文期刊>Applied Microbiology >Lactococcal 949 Group Phages Recognize a Carbohydrate Receptor on the Host Cell Surface
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Lactococcal 949 Group Phages Recognize a Carbohydrate Receptor on the Host Cell Surface

机译：乳球菌949群噬菌体识别宿主细胞表面上的碳水化合物受体。

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Lactococcal bacteriophages represent one of the leading causes of dairy fermentation failure and product inconsistencies. A new member of the lactococcal 949 phage group, named WRP3, was isolated from cheese whey from a Sicilian factory in 2011. The genome sequence of this phage was determined, and it constitutes the largest lactococcal phage genome currently known, at 130,008 bp. Detailed bioinformatic analysis of the genomic region encoding the presumed initiator complex and baseplate of WRP3 has aided in the functional assignment of several open reading frames (ORFs), particularly that for the receptor binding protein required for host recognition. Furthermore, we demonstrate that the 949 phages target cell wall phospho-polysaccharides as their receptors, accounting for the specificity of the interactions of these phages with their lactococcal hosts. Such information may ultimately aid in the identification of strains/strain blends that do not present the necessary saccharidic target for infection by these problematic phages.
机译：乳球菌噬菌体是导致乳制品发酵失败和产品不一致的主要原因之一。乳球菌949噬菌体组的一个新成员WRP3于2011年从一家西西里工厂的干酪乳清中分离出来。该噬菌体的基因组序列已确定，它构成了目前已知的最大的乳球菌噬菌体基因组，为130,008 bp。编码假定的WRP3起始物复合体和基板的基因组区域的详细生物信息学分析，有助于几个开放阅读框（ORF）的功能分配，尤其是宿主识别所需的受体结合蛋白的功能分配。此外，我们证明了949个噬菌体靶向细胞壁磷酸多糖作为它们的受体，说明了这些噬菌体与其乳球菌宿主相互作用的特异性。这样的信息最终可以帮助鉴定没有呈现出被这些有问题的噬菌体感染的必需糖靶的菌株/菌株共混物。

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