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A theoretical approach to the mechanism of jet lag using multiple-oscillator models

机译:多振子模型的时差机理的理论方法

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Jet-lag symptoms result from temporal mismatch between the internal circadian clock and external solar time. Recent experiments on mice indicate that jet lag is due to complex clock cell dynamics in the brain including desynchronization within clock cells. We consider some models possessing the hierarchical structure of clock cells in the brain. We focus primarily on the effects of light stimuli undergoing daily variation and mutual coupling between clock cells. The results reveal that jet lag corresponding to eastbound long-distance trips strongly disturbs oscillator dynamics and causes slow re-entrainment.
机译:时差症状是由于内部生物钟与外部太阳时间之间的时间不匹配而导致的。最近在老鼠身上进行的实验表明,时差反应是由于大脑中复杂的时钟细胞动力学(包括时钟细胞内的失步)引起的。我们认为某些模型具有大脑中时钟细胞的分层结构。我们主要关注光刺激的影响,这些光刺激每天都会发生变化并且时钟单元之间会相互耦合。结果表明,与东行长途旅行相对应的时差严重干扰了振荡器的动力学,并导致缓慢的重新夹带。

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