Contractivity of a genetic circuit with internal feedback and cell-to-cell communication<ce:cross-ref refid='fn1'> <ce:sup loc='post'>*</ce:sup> </ce:cross-ref> <ce:footnote id='fn1'> <ce:label>*</ce:label> <ce:note-para id='npara0001' view='all'>This research was partially funded by grant FEDER-CICYT DPI2014-55276-C5-1-R. Yadira Boada thanks grant FPI/2013-3242 of the Universitat Politècnica de Valencia.</ce:note-para> </ce:footnote>

E. Picó-Marco; Y. Boada; J. Picó; A. Vignoni

首页> 外文期刊>IFAC PapersOnLine >Contractivity of a genetic circuit with internal feedback and cell-to-cell communication * *

This research was partially funded by grant FEDER-CICYT DPI2014-55276-C5-1-R. Yadira Boada thanks grant FPI/2013-3242 of the Universitat Politècnica de Valencia.

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Contractivity of a genetic circuit with internal feedback and cell-to-cell communication * * This research was partially funded by grant FEDER-CICYT DPI2014-55276-C5-1-R. Yadira Boada thanks grant FPI/2013-3242 of the Universitat Politècnica de Valencia.

机译：具有内部反馈和细胞间通信的遗传电路的收缩性 * * 这项研究部分由FEDER-FED CICYT DPI2014-55276-C5-1-R。 Yadira Boada感谢瓦伦西亚大学（UniversitatPolitècnicade Valencia）授予FPI / 2013-3242。

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Abstract: We consider a realistic model of the synthetic gene circuit combining cell-to-cell communication system via quorum sensing, and a synthetic repressible promoter implementing intracellular negative feedback control. The circuit has been shown to increase robustness with respect to both extrinsic and intrinsic noise elsewhere. As a first step towards an analytic analysis, in this paper we use contraction theory to perform a stability analysis. From it, we infer the components of the circuit most affecting the rate of contractivity, using biologically sensible values of the circuit parameters.

机译：摘要：我们考虑了一个合成基因电路的现实模型，该模型将通过群体感应的细胞间通信系统与实现细胞内负反馈控制的合成可抑制启动子相结合。已经证明该电路相对于其他地方的外部噪声和固有噪声都提高了鲁棒性。作为进行分析的第一步，本文使用收缩理论进行稳定性分析。从中，我们使用电路参数的生物学上敏感的值推断出对收缩率影响最大的电路组件。

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《IFAC PapersOnLine》 |2016年第26期|共6页
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E. Picó-Marco; Y. Boada; J. Picó; A. Vignoni;
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中图分类自动化技术、计算机技术;
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7. Optimization Alternatives for Robust Model-based Design of Synthetic Biological Circuits**The research leading to these results has received funding from the European Union (FP7/2007-2013 under grant agreement n°604068), the Spanish Government (FEDER-CICYT DPI2011-524 28112-C04-01, DPI2014-55276-C5-1-R, DPI2015-70975-P) and the National Council of Scientific and Technologic Development of Brazil (BJT-304804/2014-2). Yadira Boada thanks also grant FPI/2013-3242 of the Universitat Politècnica de Valencia. [O] . Y. Boada, J.L. Pitarch, A. Vignoni, 2016

机译：优化替代鲁棒模型的合成生物电路设计**导致这些结果的研究已从欧盟（FP7 / 2007-2013为Grant协议N°604068），西班牙政府（Feder-icicyT DPI2011- 524 28112-C04-01，DPI2014-55276-C5-1-R，DPI2015-70975-P）和巴西的全国科技发展理事会（BJT-304804/201-2）。 Yadira Boada谢谢还赠送Politècnicadevalencia的FPI / 2013-3242。

Contractivity of a genetic circuit with internal feedback and cell-to-cell communication * * This research was partially funded by grant FEDER-CICYT DPI2014-55276-C5-1-R. Yadira Boada thanks grant FPI/2013-3242 of the Universitat Politècnica de Valencia.

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