• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Function of the Reticuloendothelial System IV. Evidence for Two Types of Particle-Induced Reticuloendothelial Paralysis
【24h】

Function of the Reticuloendothelial System IV. Evidence for Two Types of Particle-Induced Reticuloendothelial Paralysis

机译：网状内皮系统的功能IV。两种类型的颗粒引起的网状内皮麻痹的证据

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Reticuloendothelial system (RES) phagocytosis has been quantitated after intravenous injection of two different sets of particles by determining the clearance rate of subsequently injected identical or nonidentical particles. Injection of carbon produced a biphasic RES paralysis consisting of an early transient phase followed by a delayed sustained phase. The two phases were separated by a distinct interval of greatly augmented clearance rates. The injection of aggregated albumin was followed only by a single period of depressed clearance, which corresponded to the first phase of carbon-induced inhibition. This first phase, designated immediate RES paralysis, was initiated by particle injection and its duration was related to the rate of particle removal, to the dose of particles injected, and to the presence of the particles in the circulation. The second phase, designated delayed RES paralysis, began sometime after the particles had been engulfed by the cells, was independent of the rate of particle removal, and persisted without the presence of measurable particles in the circulation. The evidence indicates that the immediate paralysis arises from a competition between the particles in the circulation, whereas the delayed paralysis arises from a cellular derangement inhibitory to further phagocytosis. In contrast to the usual description of RES blockade as a single sustained period of depression, the present experiments indicate that the phenomenon has two phases which can be dissociated in time and mechanism.
机译：静脉注射两组不同的颗粒后，通过确定随后注射的相同或不同颗粒的清除率，可以量化网状内皮系统（RES）的吞噬作用。碳的注入产生了两相RES麻痹，包括早期的过渡期和随后的延迟的持续期。这两个阶段之间以明显增加的清除率间隔分开。注射聚集的白蛋白后，只有一个单一的降低的清除期，这与碳诱导的抑制作用的第一阶段相对应。第一阶段称为立即RES麻痹，是通过粒子注入开始的，其持续时间与粒子去除速率，注入的粒子剂量以及循环中粒子的存在有关。第二阶段称为延迟RES麻痹，开始于粒子被细胞吞噬后的某个时候，与粒子的去除速率无关，并且在循环中不存在可测粒子的情况下持续进行。有证据表明，立即麻痹是由循环中的颗粒之间的竞争引起的，而延迟性麻痹则是由细胞紊乱抑制到进一步的吞噬作用引起的。与通常将RES阻滞描述为一个持续的抑郁期相反，本实验表明该现象有两个阶段，可以在时间和机制上分离。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号