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首页> 外文期刊>Infection and immunity >Sensitivity of Types 1 and 2 Herpes Simplex Virus to 5-Iodo-2′-Deoxyuridine and 9-β-d-Arabinofuranosyladenine
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Sensitivity of Types 1 and 2 Herpes Simplex Virus to 5-Iodo-2′-Deoxyuridine and 9-β-d-Arabinofuranosyladenine

机译：1型和2型单纯疱疹病毒对5-碘2'-脱氧尿苷和9-β-d-阿拉伯呋喃糖基腺嘌呤的敏感性

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摘要

The sensitivities of 21 strains of herpes simplex virus (HSV), 13 type 1 strains and 8 type 2 strains, to 5-iodo-2′-deoxyuridine (IUdR) and 9-β-d-arabinofuranosyladenine (ara-A) were evaluated by the plaque-suppression test in chick embryo fibroblast (CEF), WI-38, and HeLa cell cultures. In CEF, type 1 strains were considerably more sensitive to the inhibitors than were the type 2 strains. In WI-38, the type 1 strains were more sensitive than the type 2 strains to IUdR; however, the two serotypes were equally sensitive to ara-A. In HeLa cells, the differences in sensitivity to IUdR between the two serotypes were less. Eight HeLa-adapted strains (four type 1 and four type 2) evaluated in HeLa cell cultures were equally sensitive to IUdR; the type 2 strains were slightly more sensitive than type 1 strains to ara-A. These results demonstrate the wide variation in sensitivity of HSV types 1 and 2 to antiviral agents which results from differences in the cell culture system and passage history of the strains.
机译：评估了21株单纯疱疹病毒（HSV），13株1型毒株和8株2型毒株对5-碘-2'-脱氧尿苷（IUdR）和9-β-d-阿拉伯呋喃糖基腺嘌呤（ara-A）的敏感性通过在鸡胚成纤维细胞（CEF），WI-38和HeLa细胞培养物中进行噬斑抑制试验来检测。在CEF中，1型菌株比2型菌株对抑制剂的敏感性要高得多。在WI-38中，1型菌株对IUdR的敏感性比2型菌株高。然而，两种血清型对ara-A的敏感性相同。在HeLa细胞中，两种血清型对IUdR敏感性的差异较小。在HeLa细胞培养物中评估的八种HeLa适应菌株（四个1型和四个2型）对IUdR敏感性相同。 2型菌株对ara-A的敏感性比1型菌株稍高。这些结果表明，HSV 1型和2型对抗病毒剂的敏感性差异很大，这是由于细胞培养系统和菌株的传代史不同所致。

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