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Influences of Dietary and Environmental Stress on Microbial Populations in the Murine Gastrointestinal Tract

机译：饮食和环境压力对小鼠胃肠道微生物种群的影响

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Aerobic and anaerobic cultural techniques and histological methods were used in a study of the effects of environmental and dietary stress on the indigenous microbiota of the gastrointestinal tract of mice. Mice previously inoculated with Salmonella typhimurium were examined in a similar manner. Three strains of mice (CD-1, Ha/ICr, and C57BL) were used. Control animals previously inoculated with S. typhimurium had low population levels of Salmonella bacteria in the small and large bowel. Mice previously inoculated with Salmonella and then deprived of food, water, and bedding for 48 h harbored high population levels of these bacteria in their small and large bowels. Coliforms increased in numbers in the large bowel of stressed mice inoculated with Salmonella and in the jejunum-ileum and cecum of stressed mice not previously inoculated with Salmonella. Control mice had high population levels of lactobacilli inhabiting the keratinized squamous epithelium of the stomach. Stressed mice showed dramatic reductions in these populations of lactobacilli. Populations of fusiform-shaped bacteria associated with the mucosal epithelium of the cecum and colon in control mice were reduced in stressed mice as determined by microscope examination of histological sections. Total anaerobic counts were similar, however, in both stressed and control animals. Environmental and dietary stress markedly alter the gastrointestinal microbiota in mice. Therefore, such stressful conditions profoundly affect the factors that regulate the localization and population levels of microorganisms in the stomach and intestines.
机译：有氧和无氧培养技术和组织学方法用于研究环境和饮食压力对小鼠胃肠道固有微生物群的影响。以前接种过鼠伤寒沙门氏菌的小鼠也进行了类似的检查。使用了三株小鼠（CD-1，Ha / ICr和C57BL）。先前接种过 S的对照动物。鼠伤寒在大小肠中的沙门氏菌细菌数量较低。先前用沙门氏菌接种的小鼠随后被剥夺了食物，水和床上用品48小时，这些细菌在大肠和小肠中的种群数量很高。接种沙门氏菌的应激小鼠大肠中以及未接种沙门氏菌的应激小鼠的空肠-回肠和盲肠大肠菌群数量增加。对照小鼠具有高水平的乳杆菌，其生活在胃的角化鳞状上皮中。压力大的小鼠在这些乳酸杆菌种群中显示出极大的减少。通过组织学显微镜检查，在应激小鼠中，与盲肠和结肠的粘膜上皮相关的梭形细菌的种群在应激小鼠中减少了。然而，在应激和对照动物中，总无氧菌计数相似。环境和饮食压力明显改变了小鼠的胃肠道菌群。因此，这种压力条件深刻地影响了调节胃和肠中微生物的定位和种群水平的因素。

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