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首页> 外文期刊>Infection and immunity >Immunization Against Experimental Chagas' Disease by Using Culture Forms of Trypanosoma cruzi Killed with a Solution of Sodium Perchlorate
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Immunization Against Experimental Chagas' Disease by Using Culture Forms of Trypanosoma cruzi Killed with a Solution of Sodium Perchlorate

机译：通过使用高氯酸钠溶液杀死的锥虫锥虫的培养形式对实验性南美锥虫病进行免疫接种

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Protection against infection with virulent blood (trypomastigote) forms of Trypanosoma cruzi was accomplished in mice by immunization with culture (mainly epimastigote) forms killed by treatment with sodium perchlorate. Sodium chloride, used instead of sodium perchlorate, with all other conditions kept the same, failed to kill all the organisms, indicating that the effects of the perchlorate anion were not simply ionic or osmotic, suggesting that they might be chaotropic. A single dose of the immunogen, without adjuvants, was sufficient to significantly protect against the infection. Protection was achieved by either intraperitoneal, intramuscular, or subcutaneous immunization, though the first two routes appeared to be more effective. After challenge, parasitemias were negative in 25, 29, and 17% of the animals immunized intraperitoneally, intramuscularly, and subcutaneously, respectively.
机译：通过用高氯酸钠处理杀死的培养物（主要是表鞭毛纲动物）形式的免疫接种，可在小鼠中实现针对克鲁姆氏锥虫（Trypanosoma cruzi ）的猛烈血液（锥虫纲）感染的保护。在所有其他条件保持不变的情况下，代替高氯酸钠使用的氯化钠未能杀死所有生物，这表明高氯酸根阴离子的作用不只是离子或渗透，表明它们可能是离液的。没有佐剂的单剂量免疫原足以显着预防感染。尽管前两种途径似乎更有效，但可以通过腹膜内，肌内或皮下免疫获得保护。攻击后，分别有25％，29％和17％的腹膜内，肌肉内和皮下免疫的寄生虫血症阴性。

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