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首页> 外文期刊>Infection and immunity >Phagocytosis of Cryptococcus neoformans by alveolar macrophages.
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Phagocytosis of Cryptococcus neoformans by alveolar macrophages.

机译:肺泡巨噬细胞对新隐球菌的吞噬作用。

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Guinea pig pulmonary macrophages phagocytized but did not kill nonencapsulated cells of Cryptococcus neoformans. The phagocytic process was inhibited by cryptococcal capsular polysaccharide. Pulmonary macrophages, activated by preinjecting heat-killed bacteria into intact animals, did not kill the engulfed yeast cells. Labeled cells of C. neoformans were neither killed nor cleared from guinea pig lungs 6 h postexposure. The results of our experiments indicate that during the first few hours after the lung is exposed to the infectious particle of C. neoformans the pulmonary macrophage does not function primarily to kill engulfed yeast cells. We believe that a rapid yet transient acute inflammatory response probably plays a major role in this process during the first few hours after C. neoformans enters the lung.
机译:豚鼠肺巨噬细胞被吞噬,但没有杀死新隐球菌的未包囊细胞。吞噬过程被隐球菌荚膜多糖抑制。通过将热杀死的细菌预先注入完整的动物而激活的肺巨噬细胞没有杀死被吞噬的酵母细胞。暴露后6小时,新形成梭状芽胞杆菌的标记细胞既不被杀死也不从豚鼠肺中清除。我们的实验结果表明,在肺部暴露于新感染梭状芽胞杆菌的感染颗粒后的最初几个小时内,肺巨噬细胞并不主要起杀死吞噬酵母细胞的作用。我们认为,快速而短暂的急性炎症反应可能在新孢梭菌进入肺部后的最初几个小时内在此过程中起主要作用。

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