首页> 外文期刊>IFAC PapersOnLine >Characterization of Blood Volume Space and Mitochondrial Activity in Functional Renal Cells ?
【24h】

Characterization of Blood Volume Space and Mitochondrial Activity in Functional Renal Cells ?

机译:功能性肾细胞的血容量空间和线粒体活性的表征

获取原文
           

摘要

Renal function can become compromised in the event of shock, leading to acute kidney injury (AKI). As a result, microcirculatory dysfunction and disruption of oxygen homeostastis is observed, which leads to a shift in mitochondrial bioenergetics. These events can be studied by assessing the functionality in healthy, normal states and diseased states. Characterization of the spatial heterogeneity of mitochondrial activity and capillary blood volume space in healthy renal cells was performed using intravital multi-photon microscopy. The developed metrics that were used for depiction and quantification of the physiologic normal state can be applied to a diseased state, allowing the extent of microcirculatory dysfunction to be observed and evaluated.
机译:休克时肾功能可能会受损,导致急性肾损伤(AKI)。结果,观察到微循环功能障碍和氧稳态的破坏,这导致线粒体生物能学的改变。可通过评估健康,正常状态和患病状态下的功能来研究这些事件。使用活体多光子显微镜对健康肾脏细胞中线粒体活性和毛细管血容量空间的空间异质性进行了表征。用于描述和量化生理正常状态的已开发指标可以应用于疾病状态,从而可以观察和评估微循环功能障碍的程度。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号