Endotoxin was demonstrated not to act as an adjuvant in the primary antibody response in the Syrian hamster. Minimal adjuvant action was demonstrable in antibody formation to a second injection of bovine gamma globulin. The immunological status of the hamster towards the endotoxin did not alter this weak adjuvant action. It was confirmed that the antimitotic drug colchicine will act as an adjuvant in the primary antibody response to sheep red blood cells but not to bovine gamma globulin or endotoxin in the Syrian hamster.
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