Enhancement, by Two Carboxylic Acid Interferon Inducers, of Resistance Stimulated in Mice by Foot-and-Mouth Disease Vaccine

C. H. Campbell; J. Y. Richmond

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Enhancement, by Two Carboxylic Acid Interferon Inducers, of Resistance Stimulated in Mice by Foot-and-Mouth Disease Vaccine

机译：两种羧酸干扰素诱导剂增强口蹄疫疫苗对小鼠的抵抗力

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Simultaneous injection of divinyl ether-maleic amhydride (DVE/MA) or itaconic-acrylic acid and foot-and-mouth disease virus vaccine enhanced the survival of infant mice to subsequent injections of virus. This enhanced resistance was obtained even with doses of interferon inducers which, when administered alone, failed to protect the mice. There was some increase in serum-neutralizing antibody in mice 7 days after injection of DVE/MA and vaccine, as compared with mice given vaccine alone, but there was no clear connection between antibody level and amount of DVE/MA administered.

机译：同时注射二乙烯基醚-马来酸酐（DVE / MA）或衣康丙烯酸和口蹄疫病毒疫苗可提高婴儿小鼠的存活率，因为随后注射病毒。即使使用干扰素诱导剂剂量也能获得增强的抗药性，当单独使用干扰素诱导剂时，不能保护小鼠。与单独给予疫苗的小鼠相比，注射DVE / MA和疫苗7天后的小鼠血清中和抗体有所增加，但是抗体水平与DVE / MA的给药量之间没有明确的联系。

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《Infection and immunity》 |1973年第2期|共6页
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C. H. Campbell; J. Y. Richmond;
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1. Enhanced immunogenicity of multiple-epitopes of foot-and-mouth disease virus fused with porcine interferon alpha in mice and protective efficacy in guinea pigs and swine. [J] . Du Y, Li Y, He H, Journal of Virological Methods . 2008,第1期

机译：与猪干扰素α融合的小鼠口蹄疫病毒多表位的免疫原性增强，对豚鼠和猪具有保护作用。
2. Oral pre-administration of Purslane polysaccharides enhance immune responses to inactivated foot-and-mouth disease vaccine in mice [J] . Rui Zhao, Xiangyu Meng, Guiyan Jia, BMC Veterinary Research . 2019,第1期

机译：口服预防马克酸多糖增强小鼠中灭活的脚口病疫苗的免疫反应
3. Delivery of synthetic RNA can enhance the immunogenicity of vaccines against foot-and-mouth disease virus (FMDV) in mice [J] . Borrego Belen, Rodriguez-Pulido Miguel, Mateos Francisco, Vaccine . 2013,第40期

机译：合成RNA的传递可以增强针对小鼠口蹄疫病毒（FMDV）的疫苗的免疫原性
4. Immunization of DNA vaccine encoding C3d-VP1 fusion enhanced protective immune response against foot-and-mouth disease virus [C] . Huiying FAN, Tiezhu TONG, Huanchun CHEN, Proceedings of the 3rd Congress of the Asian Pig Veterinary Society . 2007

机译：编码C3d-VP1融合蛋白的DNA疫苗的免疫增强了针对口蹄疫病毒的保护性免疫应答
5. Characterization of an interferon-induced gene identified through differential display analysis and the generation of knockout mice defective in their ability to produce interferon-induced guanylate-binding proteins. [D] . Carton, Jill Marinari. 1998

机译：通过差异显示分析鉴定的干扰素诱导基因的特征以及产生干扰素诱导鸟苷酸结合蛋白能力缺陷的基因敲除小鼠的产生。
6. Enhancement by Two Carboxylic Acid Interferon Inducers of Resistance Stimulated in Mice by Foot-and-Mouth Disease Vaccine [O] . C. H. Campbell, J. Y. Richmond 1973

机译：两种羧酸干扰素诱导剂增强口蹄疫疫苗对小鼠的抵抗力
7. Enhancement, by Two Carboxylic Acid Interferon Inducers, of Resistance Stimulated in Mice by Foot-and-Mouth Disease Vaccine [O] . C. H. Campbell, J. Y. Richmond 1973

机译：通过患有脚口疾病疫苗，通过两种羧酸干扰素诱导剂增强抗性刺激的抗性
8. 5-AED Enhances Survival of Irradiated Mice in a G-CSF-Dependent Manner, Stimulates Innate Immune Cell Function, Reduces Radiation-Induced DNA Damage and Induces Genes that Modulate Cell Cycle Progression and Apoptosis. [R] . Grace, M. B., Singh, V. K., Rhee, J. G., 2012

机译：5-aED以G-CsF依赖性方式增强辐照小鼠的存活，刺激先天免疫细胞功能，减少辐射诱导的DNa损伤并诱导调节细胞周期进展和细胞凋亡的基因。

Enhancement, by Two Carboxylic Acid Interferon Inducers, of Resistance Stimulated in Mice by Foot-and-Mouth Disease Vaccine

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