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Infection and Immunoglobulin Concentrations in Chediak-Higashi Mice

机译：Chediak-Higashi小鼠的感染和免疫球蛋白浓度

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The Chediak-Higashi syndrome (CHS) has been reported in man, cattle, mink, and mice. CHS humans and cattle have an increased incidence of pyogenic infections, whereas CHS mink are more susceptible to Aleutian disease. Age- and sex-matched groups of CHS mice (mutant strain) and C57 Bl/6N (parent strain) were challenged with Candida albicans, Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus intravenously and Streptococcus pneumoniae intraperitoneally. A significant increase (P < 0.001) in mortality rate for the CHS mice was demonstrated with all five challenge organisms. Heterozygous mice challenged with C. albicans had a mortality rate essentially the same as C57 Bl/6N mice. The serum immunoglobulin concentrations of CHS mice were found to be the same or greater than the control or heterozygous mice. CHS mice have an increased susceptibility to pyogenic infections, which is not due to immunoglobulin deficiency. These mice may provide a useful laboratory model for the study of increased susceptibility to infection.
机译：Chediak-Higashi综合征（CHS）已在人，牛，貂和小鼠中报道。 CHS人和牛的化脓性感染发生率增加，而CHS貂更易患阿留申氏病。 CHS小鼠（突变株）和C57 Bl / 6N（亲本株）的年龄和性别匹配的组分别受到白色念珠菌，大肠杆菌，肺炎克雷伯菌和金黄色葡萄球菌的攻击肺炎链球菌和肺炎链球菌。在所有5种攻击生物中，CHS小鼠的死亡率均显着增加（ P <0.001）。用 C攻击的杂合小鼠。白色念珠菌的死亡率基本上与C57 Bl / 6N小鼠相同。发现CHS小鼠的血清免疫球蛋白浓度与对照或杂合小鼠相同或更高。 CHS小鼠对化脓性感染的敏感性增加，这不是由于免疫球蛋白缺乏引起的。这些小鼠可以为研究增加的感染敏感性提供有用的实验室模型。

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