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首页> 外文期刊>Infection and immunity >Leukocyte Dysfunction in the Bovine Homologue of the Chediak-Higashi Syndrome of Humans
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Leukocyte Dysfunction in the Bovine Homologue of the Chediak-Higashi Syndrome of Humans

机译：人的化学-东综合征的牛同源物中的白细胞功能障碍

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The increased susceptibility to pyogenic infections noted in cattle with the Chediak-Higashi syndrome trait has been related to an impairment of leukocyte function at the cellular level. Investigations of the relationship of abnormal granule formation to increased susceptibility to infection, conducted with cell suspensions containing high concentrations of polymorphonuclear leukocytes, revealed a bactericidal defect that was associated with abnormal intracellular killing and not due to defective particle ingestion. The in vitro bactericidal defect was associated with a metabolic anomaly in the hexose monophosphate shunt, but not with an alteration in the capacity to reduce nitroblue tetrazolium dye. Ultrastructural histochemical studies of phagocytosis and phagolysosome formation in polymorphonuclear leukocytes suggest that the impairment in bactericidal capacity is correlated also with either a delay or failure of primary granules to degranulate.
机译：具有Chediak-Higashi综合征特征的牛对化脓性感染的易感性增加与细胞水平的白细胞功能受损有关。对含有高浓度多形核白细胞的细胞悬浮液进行的异常颗粒形成与感染敏感性增加之间关系的研究显示，其杀菌缺陷与细胞内异常杀伤有关，而不是由于摄入不良颗粒所致。体外杀菌缺陷与己糖一磷酸分路中的代谢异常有关，但与还原硝基蓝四唑鎓染料的能力没有变化。在多形核白细胞中吞噬作用和吞噬溶酶体形成的超微结构化学研究表明，杀菌能力的损害还与初级颗粒脱粒的延迟或失败有关。

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