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首页> 外文期刊>Infection and immunity >Variations in properties of L-forms of Pseudomonas aeruginosa.
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Variations in properties of L-forms of Pseudomonas aeruginosa.

机译：铜绿假单胞菌L型的性质变异。

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In a study of the pathogenic potentials of Pseudomonas L-forms, three unstable L-forms were derived by carbenicillin inductionfrom a mouse virulent strain of Pseudomonas aeruginosa, Rosenthal 180. One L-form, induced on a sucrose-stabilized medium, grew more slowly and differed in a number of properties from two other L-forms induced on a medium supported with polyvinylpyrilidone. After adaptation to a common liquid medium, the three L-forms differed with respect to colonial shape on solid medium, growth rate, certain biochemical properties, antibiotic sensitivities and antigenic surface, and virulence for mice. The L-form may revert in vitro to a serotype different from that of the parent culture. The revertant may acquire new antibiotic resistances and sensitivities in the absence of previous exposure to the drugs and enhanced resistance to the L-inducing agent. The three L-forms showed a characteristically lower, but wide, range of virulence than did the parental form. Though death of mice was accompanied by reversion of the L-forms in vivo to the bacterial form, reversion in vivo was not necessary for virulence of L-forms. Modification of residual cell wall antigens accompanied the induction of each L-form as determined by type-specific antisera.
机译：在对假单胞菌L型致病性的研究中，通过羧苄青霉素诱导从铜绿假单胞菌的强毒株Rosenthal 180衍生出三种不稳定的L型。在蔗糖稳定的培养基上诱导的一种L型生长较慢。并且在许多性质上不同于在聚乙烯吡咯烷酮负载的培养基上诱导的其他两种L型。适应普通液体培养基后，三种L型在固体培养基上的菌落形状，生长速率，某些生化特性，抗生素敏感性和抗原表面以及小鼠的毒力方面有所不同。 L型可以在体外恢复为不同于亲本培养物的血清型。在不事先接触药物的情况下，还原剂可能会获得新的抗生素抗性和敏感性，并且对L诱导剂的抗性增强。与亲本形式相比，三种L形式的毒力特征性地较低，但范围较广。尽管小鼠的死亡伴随着体内L-形式向细菌形式的逆转，但是对于L-形式的毒性来说，体内逆转不是必需的。残留细胞壁抗原的修饰伴随由类型特异性抗血清确定的每种L型的诱导。

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